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    Vadakekolathu J, Lai C, Reeder S, Church SE, … DiPersio JF, Davidson-Moncada JK, Rutella S TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML, , Blood Adv , Oct 15, 2020

    Riviere E, Pascaud J, Virone A...Poirier N, Mariette X, Nocturne G Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjogren's syndrome., , Arthritis Rheumatol, Oct 15, 2020

    Vitorino P, Chuang CH, Iannello A, Zhao X, Anderson W, Ferrando R, Zhang Z, Madhavan S, Karsunky H, Saunders LR Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression., , Transl Oncol, Oct 15, 2020

    Chau I, Penel N, Soriano AO...Ferry D, Herbst RS, Fuchs CS Ramucirumab in Combination with Pembrolizumab in Treatment-Naïve Advanced Gastric or GEJ Adenocarcinoma: Safety and Antitumor Activity from the Phase 1a/b JVDF Trial., , Cancers (Basel), Oct 15, 2020

    Herbst RS, Arkenau HT, Bendell J...Ferry D, Chao BH, Paz-Ares L Phase 1 Expansion Cohort of Ramucirumab Plus Pembrolizumab in Advanced Treatment-Naive Non-Small Cell Lung Cancer., , J Thorac Oncol, Oct 14, 2020

    Wiesweg M, Mairinger F, Reis H...Schmid KW, Rahmann S, Schuler M Machine learning reveals a PD-L1-independent prediction of response to immunotherapy of non-small cell lung cancer by gene expression context., , Eur J Cancer, Oct 12, 2020

    Lowe PP, Morel C, Ambade A...Seyedkazemi S, Schafer DP, Szabo G Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations., , J Neuroinflammation, Oct 09, 2020

    Yau C, Gan ES, Kwek SS...Watanabe S, Vasudevan SG, Ooi EE Live vaccine infection burden elicits adaptive humoral and cellular immunity required to prevent Zika virus infection., , EBioMedicine, Oct 09, 2020

    Akata K, Yamasaki K, Leitao Filho FS...Leung JM, Sin DD, van Eeden SF Abundance of Non-Polarized Lung Macrophages with Poor Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)., , Biomedicines, Oct 09, 2020

    Jones CI, Rose SL, Shutt A, Cairo C, Bourgeois NM, Charurat M, Sodora DL, Wood MP Maternal HIV status skews transcriptomic response in infant cord blood monocytes exposed to BCG., , AIDS, Oct 08, 2020

    Li Y, Ritzel RM, He J, Cao T, Sabirzhanov B, Li H, Liu S, Wu LJ, Wu J The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation., , Brain Behav Immun, Oct 08, 2020

    Davis JE, Handunnetti SM, Ludford-Menting M...Tam CS, Ritchie DS, Koldej RM Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy., , Blood Adv, Oct 08, 2020

    Thompson JC, Davis C, Deshpande C, Hwang WT, Jeffries S, Huang A, Mitchell TC, Langer CJ, Albelda SM Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma., , J Immunother Cancer, Oct 07, 2020

    Browning LM, Miller C, Kuczma M, Pietrzak M, Jing Y, Rempala G, Muranski P, Ignatowicz L, Kraj P Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells., , Cell Rep, Oct 06, 2020

    Gibson JT, Orlandella RM, Turbitt WJ, Behring M, Manne U, Sorge RE, Norian LA Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer., Nearly 70% of adults in the US are currently overweight or obese. Despite such high prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes remains incompletely understood, particularly in patients with breast cancer. Here, we addressed these gaps in knowledge using two murine models of breast cancer combined with diet-induced obesity. We report that obesity increases CXCL1 concentrations in the mammary tumor microenvironment, driving CXCR2-mediated chemotaxis and accumulation of granulocytic myeloid-derived suppressor cells (G-MDSCs) expressing Fas ligand (FasL). Obesity simultaneously promotes hyperactivation of CD8 tumor-infiltrating lymphocytes (TILs), as evidenced by increased expression of CD44, PD-1, Ki-67, IFNγ, and the death receptor Fas. Accordingly, G-MDSCs induce Fas/FasL-mediated apoptosis of CD8 T cells ex vivo and in vivo. These changes promote immunotherapy resistance in obese mice. Disruption of CXCR2-mediated G-MDSC chemotaxis in obese mice is sufficient to limit intratumoral G-MDSC accumulation and improve immunotherapy outcomes. The translational relevance of our findings is demonstrated by transcriptomic analyses of human breast tumor tissues, which reveal positive associations between CXCL1 expression and body mass index, poor survival, and a MDSC gene signature. Further, this MDSC gene signature is positively associated with FASLG expression. Thus, we have identified a pathway wherein obesity leads to increased intratumoral CXCL1 concentrations, which promotes CXCR2-mediated accumulation of FasL+ G-MDSCs, resulting in heightened CD8 TIL apoptosis and immunotherapy resistance. Disruption of this pathway may improve immunotherapy outcomes in patients with breast cancer and obesity., Front Immunol, Oct 06, 2020