Identify cellular malfunction and dysregulated pathways
nCounter® direct hybridization-based digital counting technology allows for a multiplex approach to simultaneously analyze dozens of pathways and cell composition from a single precious sample. Neuroscience researchers around the world are already using this technology to quickly and efficiently perform research on gene expression profiling, response to drug treatment, signature generation, and biomarker characterization.
Published examples using nCounter in Neuroscience include:
- Angiotensinogen and HLA class II predict Bevacizumab response in recurrent glioblastoma patients
- Transcriptomic comparison of sorted mouse cells to establish microglia gene signatures
- Analysis of iPSC’s to confirm C9ORF72 repeat expansion in ALS patients
- Evaluation of α-synuclein gene transcripts in Parkinson’s disease patients using whole blood samples
Human and Mouse panels including 770 genes that enable the research of 23 neurodegenerative pathways/processes and the measurement of five neural cell types.
Butovsky O. et al., Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice., [Epub ahead of print]., Annals of Neurology, Nov 10, 2014
Donnelly C.J. et al., RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention., 80(2):415-428, Neuron, Oct 16, 2013
Liao M-C. et al., Single-Cell Detection of Secreted Aβ and sAPPα± from Human IPSC-Derived Neurons and Astrocytes., [Epub ahead of print]., J. Neuroscience, Feb 03, 2016
Locascio J.J. et al., Association between α±-synuclein blood transcripts and early, neuroimaging-supported Parkinson՚s disease., [Epub ahead of print]., Brain, Jul 28, 2015
Mayo L. et al., IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation., [Epub ahead of print]., Brain, May 31, 2016
Urup T. et al., Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients., Molecular Oncology, May 26, 2016
Click here to view all nCounter publications on neuroscience.
For Research Use Only. Not for use in diagnostic procedures.