Curbing the Threat of Infectious Diseases

Multiplexed Infectious Disease Analysis

In this whitepaper "Multiplexed Infectious Disease Analysis," you can learn how NanoString’s nCounter® platform provides a simple workflow to enable rapid, precise, and cost-effective infectious disease research and diagnosis.

 

Identify Pathogens and Study the Host Immune Response

The threat of infectiousdisease continues to grow globally with the rise of new pathogens such as SARs-CoV-2 and influenza Type A H1N1. Infectious disease research plays an important role in developing vaccines and medications to reduce the devastating effects of serious illnesses and infections caused by HIV, Ebola virus, Zika virus, and Influenza virus, or even the common cold. Research on host responses to bacterial or fungal infections may also aid in the development of new treatments for antibiotic resistant strains that are reemerging as a public health threat.

Current infectious disease research is aimed at understanding how pathogens function and how hosts respond, but these efforts can be complicated due to multiple variables such as sample availability, pathogen load, and time to identification. Further complicating things, when specimens are available, pathogens may constitute a small fraction of the sample, and readings must be made quickly to inform treatment decisions. These measurements are crucial because by tracking the immune response to bacteria, viruses, fungi, and parasites, investigators can gain insight into potential therapeutic pathways. For accurate pathogen identification, particularly, there is a need for technologies that accurately assess the host immune response while tracking transcriptional profiles in vivo, where gene expression may differ significantly from patterns observed in vitro.

New direct hybridization-based digital counting technologies allow for a multiplex approach to profile both pathogen and host-specific responses simultaneously. Scientists around the world can use the nCounter® Analysis System and the GeoMx® Digital Spatial Profiler to understand the immune response to COVID-19 disease, identify key changes in T cell function during Tuberculosis infection, and rapidly identify antibiotic resistance, among others.



For Research Use Only. Not for use in diagnostic procedures.