Develop Therapies that Harness the Immune System in a Controlled and Rational Way
Significant advances in immunology over the last decade have improved our ability to harness the immune system to treat disease and prevent excess inflammatory response without harming healthy tissue. Researchers are undertaking collective studies of whole animals, organs and tissues, cells, and molecular pathways to gain an improved understanding of the mechanisms that characterize the immune response, including the role of the host, the environment and the disease.
Using 3D Biology™ Technology for the simultaneous evaluation of DNA single-nucleotide variants, mRNA changes, protein changes, and post-translational modifications, researchers are profiling disease and the immune response in both human clinical samples and mouse models. Their findings provide meaningful insight into a wide range of human diseases, including cancer, auto-immune disease, and infectious disease.
Immunology research aids in the development of new treatments that provide specific destruction of disease cells with no toxicity of normal tissue and with long-term memory that prevents recurrence. Moreover, this newfound knowledge will contribute to our predictions for who will respond to these therapies.
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Urrutia A et al., "Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses" Cell Reports [Epub ahead of print]. August 25, 2016
Ohta T. et al., "Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis" Sci. Reports [Epub ahead of print]. March 23, 2016
Wang C. et al., "CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity" Cell [Epub ahead of print]. November 19, 2015
Tom J.K. et al., "Modulation of Innate Immune Responses Covalently Linked TLR Agonists." ACS [Epub ahead of print]. October 28, 2015
Kurtulus S. et al., "TIGIT predominantly regulates the immune response via regulatory T cells ." JCI [Epub ahead of print]. September 28, 2015
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