Masthead

Extract the most out of precious neuroscience samples

Masthead

Neurodegeneration, neuroinflammation, infectious disease, and neurotrauma can have devastating effects on the Central Nervous System (CNS) that impact cognitive function, behavior, mental health, and more. Understanding the role of CNS cells such as neurons, astrocytes, glia, and oligodendrocytes as well as the pathways involved in disorders such as Alzheimer’s, Parkinson’s, Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis (MS) is crucial to disease prevention, detection, and treatment. 

Challenges

We know it’s difficult to acquire diseased and normal CNS tissue for research. When samples are available, extracting the most biological information from every experiment with a multi-omic platform that is easy to use is important. Traditional, low-plex methods of profiling RNA and protein such as PCR, western blotting, immunohistochemistry, or immunofluorescence staining provide limited information on CNS structure and functionality.  RNA Sequencing, while more comprehensive for expression analysis, does not directly quantify transcripts, requires time-consuming, tedious steps and onerous data analysis and sacrifices the spatial arrangement of mRNAs within tissue.


NanoString offers two robust and widely-cited platforms for multiplexed proteomics and transcriptomics of challenging neuroscience sample types such as FFPE, cell lysates, and cerebrospinal fluid. The nCounter® Analysis System and GeoMx® Digital Spatial Profiler (DSP) can be used in tandem with minimal hands-on time for bulk and spatial profiling of RNA or protein to generate accurate, repeatable, and insightful results in less than 24 hours that get you to your next neuroscience publication faster.

Case
Studies

Biomarkers for Parkinson’s
Disease – Case Study

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Biomarkers for Parkinson’s Disease - Case Study

Inflammation in Alzheimer’s
– Case Study

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Inflammation in Alzheimer's Case Study

Microglia and Alzheimer’s
– Case Study

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Inflammation in Alzheimer's - Case Study

Related Resources

View All Resources
Blog Advancing Neuroscience Gene Expression Research
Whitepaper Neuro Pub Review – Whitepaper
Product Bulletin nCounter Neuroinflammation Panel – Product Bulletin
Product Bulletin nCounter Neuropathology Panel – Product Bulletin
App Note/Tech Note The importance of Gene Expression in Neurodegenerative Disease Research – App Note

Retrospective Validation of a 168-Gene Expression Signature for Glioma Classification on a Single Molecule Counting Platform.

Gene expression profiling has been shown to be comparable to other molecular methods for glioma classification. We sought to validate a gene-expression based glioma classification method.

Supratentorial ependymoma in childhood: more than just RELA or YAP.

Two distinct genetically defined entities of ependymoma arising in the supratentorial compartment are characterized by the presence of either a C11orf95-RELA or a YAP-MAMLD1 fusion, respectively. There is growing evidence that supratentorial ependymomas without these genetic features exist.

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits.

Background: Disruptions of brain-gut axis have been implicated in the progression of a variety of gastrointestinal (GI) disorders and central nervous system (CNS) diseases and injuries, including traumatic brain injury (TBI). TBI is a chronic disease process characterized by persistent secondary injury processes which can be exacerbated by subsequent challenges.