Stem Cell Therapy and Regenerative Medicine
Solutions for Stem Cell Therapy Research
From measuring stem cell pluripotency to deep molecular characterization of pluripotent stem cells, assessing cell culture conditions and exploring organoid tissue function, together we can advance the field of regenerative medicine and improve the human condition.
- Deeply characterize pluripotent stem cells
- Optimize stem cell development
- Evaluate viability, confirm functionality, & determine pluripotency
- Detect mycoplasma contamination
- Assess neurological cell types
- Characterize neuronal tissue function
- Assess cell culture conditions
- Fully elucidate alterations in metabolic pathways, signaling pathways, and cell stress
Directly reprogrammed Huntington’s disease neural precursor cells generate striatal neurons exhibiting aggregates and impaired neuronal maturation.
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by the progressive loss of striatal medium spiny neurons. Using a highly efficient protocol for direct reprogramming of adult human fibroblasts with chemically modified mRNA, we report the first generation of HD induced neural precursor cells (iNPs) expressing striatal lineage markers that differentiated into DARPP32+ neurons from individuals with adult-onset HD (41-57 CAG).
Modeling Psychiatric Disorder Biology with Stem Cells.
Purpose of Review: We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene-editing and directed cell differentiation. Recent Findings: The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study psychiatric disease.
Andrographolide promotes proliferative and osteogenic potentials of human placenta-derived mesenchymal stem cells through the activation of Wnt/β-catenin signaling.
Introduction: The in vitro expansion and differentiation of mesenchymal stem cells derived from bone marrow (BM-hMSCs) are considered as potential therapeutic tools for clinical applications in bone tissue engineering and regenerative medicine. However, invasive sampling and reduction in number and proliferative capacity with age are the major limitations of BM-hMSCs.