Stem Cell Therapy and Regenerative Medicine
Solutions for Stem Cell Therapy Research
From measuring stem cell pluripotency to deep molecular characterization of pluripotent stem cells, assessing cell culture conditions and exploring organoid tissue function, together we can advance the field of regenerative medicine and improve the human condition.
- Deeply characterize pluripotent stem cells
- Optimize stem cell development
- Evaluate viability, confirm functionality, & determine pluripotency
- Detect mycoplasma contamination
- Assess cell culture conditions
- Fully elucidate alterations in metabolic pathways, signaling pathways, and cell stress
Translational investigation of electrophysiology in hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) patients are at increased risk of ventricular arrhythmias and sudden cardiac death, which can occur even in the absence of structural changes of the heart. HCM mouse models suggest mutations in myofilament components to affect Ca2+ homeostasis and thereby favor arrhythmia development.
Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice.
Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many inflammatory and degenerative diseases.
SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network.
Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer’s disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer’s disease, and SORL1 variants increase risk for late-onset AD.