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CAR-T Cellular Therapy Development

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CAR-T Cellular Therapy Solutions

From optimizing CAR-T cell design and evaluating pre-clinical models to discovering response biomarkers and mechanisms of action, together we can advance the field of cellular therapy and improve the human condition.

Publications

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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required.

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial.

Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have shown remarkable activity in B cell acute lymphoblastic leukemia (B-ALL). The major cause of treatment failure is antigen downregulation or loss.

A novel non-viral delivery method that enables efficient engineering of primary human T cells for ex vivo cell therapy applications.

Background aims: Next-generation immune cell therapy products will require complex modifications using engineering technologies that can maintain high levels of cell functionality. Non-viral engineering methods have the potential to address limitations associated with viral vectors.

Spotlight on CAR-T

Webinar New Approaches for CAR-T Cell Therapies: Technology Symposium featuring GeoMx spatial profiling and nCounter CAR-T Characterization
Webinar Murine March Madness: Contextual reprogramming of CAR-T cells for the treatment of HER2-expressing cancers
Blog Q&A with Dr. Lisa Butterfield, PhD: Cancer Vaccines & Adoptive Cell Transfer
Blog SITC in Focus: CAR-T Cell Therapy
Poster Molecular Characterization for CAR-T Cell Therapy-Poster

Related Resources

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Product Bulletin CAR-T Characterization Panel – Product Bulletin
Blog Q&A with Dr. Lisa Butterfield, PhD: Cancer Vaccines & Adoptive Cell Transfer
Blog SITC in Focus: CAR-T Cell Therapy
Poster CAR-T EU Congress 2019 Poster – A Step Toward Standardization with the nCounter® CAR-T Characterization Panel
Product Bulletin nCounter® Stem Cell Characterization Panel Product Bulletin
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