Recent human genetic errors of innate immunity leading to increased susceptibility to infection

Leen Moens; Isabelle Meyts

doi:10.1016/j.coi.2019.12.002

Recent human genetic errors of innate immunity leading to increased susceptibility to infection

Curr Opin Immunol. 2020 Feb:62:79-90. doi: 10.1016/j.coi.2019.12.002. Epub 2020 Jan 11.

Authors

Leen Moens¹, Isabelle Meyts²

Affiliations

¹ Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium.
² Laboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. Electronic address: isabelle.meyts@uzleuven.be.

PMID: 31935567
DOI: 10.1016/j.coi.2019.12.002

Abstract

The germline encoded innate immunity governs eukaryotic host defense through both hematopoietic and non-hematopoietic cells, whereas adaptive immunity actions mainly via T cells and B cells characterized by their somatic genetic diversification of antigen-specific responses. Human inborn errors of innate immunity typically underlie infectious diseases. Disturbed innate immunity can additionally result in auto-inflammation. Here, we review inborn errors of innate immunity that have been recently discovered as well as new insights into previously described inborn errors of innate immunity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacterial Infections / immunology*
Genetic Diseases, Inborn / immunology*
Humans
Immunity, Innate / immunology*
Mycoses / immunology*
Virus Diseases / immunology*