Novel mediators of aneurysm progression in bicuspid aortic valve disease.
J Mol Cell Cardiol. 2019.
PMID: 31047984
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Novel mediators of aneurysm progression in bicuspid aortic valve disease.
Tobin SW, Alibhai FJ, Lee MM, Yeganeh A, Wu J, Li SH, Guo J, Tsang K, Tumiati L, Rocha R, Butany J, Yau TM, Ouzounian M, David TE, Weisel RD, Li RK.
Tobin SW, et al.
J Mol Cell Cardiol. 2019 Jul;132:71-83. doi: 10.1016/j.yjmcc.2019.04.022. Epub 2019 Apr 29.
J Mol Cell Cardiol. 2019.
PMID: 31047984
Bicuspid aortic valve (BAV) disease is a congenital abnormality that is associated with ascending aortic aneurysm yet many of the molecular mechanisms remain unknown. ...Upstream analysis of AP-1 regulation showed that the ERK1/2 signalin …
Bicuspid aortic valve (BAV) disease is a congenital abnormality that is associated with ascending aortic …
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Bicuspid Aortic Valve and Endothelial Dysfunction: Current Evidence and Potential Therapeutic Targets.
Antequera-González B, Martínez-Micaelo N, Alegret JM.
Antequera-González B, et al.
Front Physiol. 2020 Aug 21;11:1015. doi: 10.3389/fphys.2020.01015. eCollection 2020.
Front Physiol. 2020.
PMID: 32973551
Free PMC article.
Review.
Bicuspid aortic valve (BAV), the most frequent congenital heart malformation, is characterized by the presence of a two-leaflet aortic valve instead of a three-leaflet one. BAV disease progression is associated with valvular dysfun …
Bicuspid aortic valve (BAV), the most frequent congenital heart malformation, is characterized by the presence of a two …
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Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA.
Blaser MC, et al.
Circ Res. 2018 Feb 2;122(3):405-416. doi: 10.1161/CIRCRESAHA.117.311194. Epub 2017 Dec 22.
Circ Res. 2018.
PMID: 29273600
RATIONALE: Aortic valve disease is a cell-mediated process without effective pharmacotherapy. ...CONCLUSIONS: Our data establish CNP/NPR2 signaling as a novel regulator of aortic valve development and disease and elucidate t …
RATIONALE: Aortic valve disease is a cell-mediated process without effective pharmacotherapy. ...CONCLUSIONS: Ou …
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The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study.
Pisano C, Terriaca S, Scioli MG, Nardi P, Altieri C, Orlandi A, Ruvolo G, Balistreri CR.
Pisano C, et al.
Int J Mol Sci. 2022 Sep 16;23(18):10848. doi: 10.3390/ijms231810848.
Int J Mol Sci. 2022.
PMID: 36142762
Free PMC article.
The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well understood and only partially characterized. ...Here, we examined the involvement of ERG-related pathways in the differential progression of disease in aortic …
The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well understood and only partially characteri …
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