Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1487-1503. doi: 10.1161/ATVBAHA.121.315896. Epub 2021 Feb 11.

Authors

Stefan Haemmig^#¹, Ali Hashemi Gheinani^#^{2

3}, Marina Zaromytidou¹, Gerasimos Siasos¹, Ahmet Umit Coskun¹, Michelle A Cormier¹, David A Gross¹, A K M Khyrul Wara¹, Antonios P Antoniadis¹, Xinghui Sun¹, Galina K Sukhova¹, Fred G P Welt⁴, Ioannis Andreou¹, Carl Whatling⁵, Li-Ming Gan⁵, Johannes Wikström, Elazer R Edelman^{1

6}, Peter Libby¹, Peter H Stone¹, Mark W Feinberg¹

Affiliations

¹ Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
² Department of Surgery, Urological Diseases Research Center, Boston Children Hospital (A.H.G.), Harvard Medical School, Boston, MA.
³ Broad Institute of MIT and Harvard, Cambridge, MA (A.H.G.).
⁴ Division of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City (F.G.P.W.).
⁵ Bioscience Cardiovascular/Early Clinical Development/Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (C.W., L.-M.G., J.W.).
⁶ Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge (E.R.E.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: algorithms; atherosclerosis; coronary vessels; mitochondria; technology.

Publication types

Comparative Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Grants and funding