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Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome.
Kelley CM, Ginsberg SD, Alldred MJ, Strupp BJ, Mufson EJ. Kelley CM, et al. Dev Neurobiol. 2019 Jul;79(7):664-683. doi: 10.1002/dneu.22700. Epub 2019 Jun 9. Dev Neurobiol. 2019. PMID: 31120189 Free PMC article.
Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD). Although da
Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of t
Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline supplementation.
Alldred MJ, Pidikiti H, Heguy A, Roussos P, Ginsberg SD. Alldred MJ, et al. FASEB J. 2023 Jun;37(6):e22944. doi: 10.1096/fj.202202111RR. FASEB J. 2023. PMID: 37191946
Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alzheimer's disease (AD). ...DEGs within these identified pathways may underlie aberrant behavior in the DS mice, with MCS attenuating t
Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome (DS) and Alz
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.
Alldred MJ, Chao HM, Lee SH, Beilin J, Powers BE, Petkova E, Strupp BJ, Ginsberg SD. Alldred MJ, et al. Hippocampus. 2018 Apr;28(4):251-268. doi: 10.1002/hipo.22832. Epub 2018 Feb 12. Hippocampus. 2018. PMID: 29394516 Free PMC article.
Further, no effective treatment exists to combat intellectual disability and basal forebrain cholinergic neurodegeneration seen in DS. To further our understanding of gene expression changes before and following cholinergic degeneration i …
Further, no effective treatment exists to combat intellectual disability and basal forebrain cholinergic neurodegenerat …