OLD Category: methods

August 3, 2023 / Cancer Med

  • Byeon S, du Toit-Thompson T, Gillson J, Gill AJ, Samra JS, Mittal A, Sahni S
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies in the world, for which the mortality is almost as high as the disease incidence and is predicted to…
July 24, 2023 / Nat Microbiol

  • Speranza E
Although virus-host interactions are usually studied in a single cell type using in vitro assays in immortalized cell lines or isolated cell populations, it is important to remember that what…
July 18, 2023 / Brief Bioinform

  • Wang J, Horlacher M, Cheng L, Winther O
RNA localization is essential for regulating spatial translation, where RNAs are trafficked to their target locations via various biological mechanisms. In this review, we discuss RNA localization in the context…
July 15, 2023 / Biophys Rev

  • Wang X, Wu X, Hong N, Jin W
With the rapid advance of single-cell sequencing technology, cell heterogeneity in various biological processes was dissected at different omics levels. However, single-cell mono-omics results in fragmentation of information and could…
July 15, 2023 / Br J Cancer

  • Wang MM, Coupland SE, Aittokallio T, Figueiredo CR
Immune checkpoint therapies (ICT) can reinvigorate the effector functions of anti-tumour T cells, improving cancer patient outcomes. Anti-tumour T cells are initially formed during their first contact (priming) with tumour…
July 13, 2023 / J Pharm Anal

  • Zhou Y, Xinyi Jiang, Xiangyi Wang, Jianpeng Huang, Tong Li, Hongtao Jin, Jiuming He
Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate structures. By interacting with the microenvironment, tumor cells undergo dynamic changes in gene expression and metabolism, resulting in…
July 6, 2023 / Biosensors

  • Shi J, Pan Y, Liu X, Cao W, Mu Y, Zhu Q
Spatial profiling technologies fill the gap left by the loss of spatial information in traditional single-cell sequencing, showing great application prospects. After just a few years of quick development, spatial…
July 3, 2023 / Nat Aging

  • Gurkar AU, Gerencser AA, Mora AL, Nelson AC, Zhang AR, Lagnado AB, Enninful A, Benz C, Furman D, Beaulieu D, Jurk D, Thompson EL, Wu F, Rodriguez F, Barthel G, Chen H, Phatnani H, Heckenbach I, Chuang JH, Horrell J, Petrescu J, Alder JK, Lee JH, Niedernhofer LJ, Kumar M, Königshoff M, Bueno M, Sokka M, Scheibye-Knudsen M, Neretti N, Eickelberg O, Adams PD, Hu Q, Zhu Q, Porritt RA, Dong R, Peters S, Victorelli S, Pengo T, Khaliullin T, Suryadevara V, Fu X, Bar-Joseph Z, Ji Z, Passos JF
Cellular senescence is a well-established driver of aging and age-related diseases. There are many challenges to mapping senescent cells in tissues such as the absence of specific markers and their…
July 2, 2023 / VIEW

  • He L, Wenjia Wang, Kaitong Dang, Qinyu Ge, Xiangwei Zhao
Cells are basic building blocks of life with vast heterogeneity. Nowadays, the rapid development of single-cell multiomics (scMulti-Omics) has facilitated comprehensive understanding of gene regulatory networks, cellular characteristics, and temporal…
July 2, 2023 / Semin Cancer Biol

  • Yuan Z, Yao J
Spatially resolved transcriptomics (SRT) has unlocked new dimensions in our understanding of intricate tissue architectures. However, this rapidly expanding field produces a wealth of diverse and voluminous data, necessitating the…
June 27, 2023 / DNA Repair (Amst)

  • Krieger KL, Mann EK, Lee KJ, Bolterstein E, Jebakumar D, Ittmann MM, Dal Zotto VL, Shaban M, Sreekumar A, Gassman NR
DNA adducts and strand breaks are induced by various exogenous and endogenous agents. Accumulation of DNA damage is implicated in many disease processes, including cancer, aging, and neurodegeneration. The continuous…
June 12, 2023 / Signal Transduct Target Ther

  • Li X
In a recent publication in Nature,1 Zhang et al. have developed spatial ATAC-RNA-seq and spatial CUT&Tag-RNA-seq as innovative tools that enable the high-resolution mapping of epigenetic and transcriptomic features in…