OLD Category: lung disease

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

• Roper N, Velez MJ, Chiappori A, Kim YS, Wei JS, Sindiri S, Takahashi N, Mulford D, Kumar S, Ylaya K, Trindade C, Manukyan I, Brown AL, Trepel JB, Lee JM, Hewitt S, Khan J, Thomas A

Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition

• Wang Q, Sundar IK, Lucas JH, Muthumalage T, Rahman I

NGS‐based liquid biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step toward personalized NSCLC treatment

• Sánchez‐Herrero E, Serna‐Blasco R, Ivanchuk V...González‐Rumayor V, Provencio M, Romero A

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

• Chenery AL, Rosini S, Parkinson JE...Kadler KE, Sutherland TE, Allen JE

SU5416 plus hypoxia but not selective VEGFR2 inhibition with cabozantinib plus hypoxia induces pulmonary hypertension in rats: potential role of BMPR2 signaling

• Sitapara R, Sugarragchaa C, Zisman LS

3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway

• Chen KY, Tseng CH, Feng PH...Liu WT, Lee KY, Wu SM

A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

• Idris A, Davis A, Supramaniam A...Scott TA, McMillan NA, Morris KV

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

• Dejima H, Hu X, Chen R...Kadara H, Wistuba II, Zhang J

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers

• Peng DH, Rodriguez BL, Diao L...Wang J, Byers LA, Gibbons DL

Intra-tumoral CD39(+)CD8(+) T cells predict response to PD-1/PD-L1 blockade in patients with NSCLC

• Yeong J, Suteja L, Simoni Y...Hon Lim TK, Newell EW, Tan DSW

Calprotectin-mediated zinc chelation inhibits Pseudomonas aeruginosa protease activity in cystic fibrosis sputum

• Vermilyea DM, Crocker AW, Gifford AH, Hogan DA

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

• Delorey TM, Ziegler CGK, Heimberg G...Villani AC, Rozenblatt-Rosen O, Regev A