Vantage 3D™ Assays
Helping Your Research
NanoString is pioneering the field of 3D Biology to accelerate the rate of research and maximize the amount of information that can be generated from a single sample. 3D Biology™ Technology is the ability to analyze combinations of RNA and protein simultaneously in a single experiment. Based on the NanoString digital barcode technology and designed for flexibility, the nCounter Vantage 3D Portfolio of assays provides a deeper view of cancer and immune biology and can be mixed and matched to answer a wide variety of biological questions.
How It Works
The nCounter Vantage 3D portfolio is designed for flexibility. Each panel can also be run as a stand-alone assay so you can generate the data you need. Select the right targeted panels for each analyte type, and detect and analyze them all at once with the nCounter Analysis System and nSolver™ software.
With the Vantage 3D portfolio, you can mix and match content based on your research needs with multi-analyte assays for Immuno-Oncology and Solid and Heme Tumor Profiling.
Panel Selection Tool
Find the gene expression panel for your research with easy to use panel proFind Your Panel
Vantage 3D RNA Panels
Vantage 3D Fusion Panels
Vantage 3D Protein Panels
Panel Compatibility and Customization
Each panel can be run as a stand-alone assay with customization available. Up to 24 user- defined genes can be added to any Vantage 3D RNA panel, including fusion panels. Up to five custom protein targets can be added to any Vantage 3D Protein panel using the Protein Barcoding Service.
Unsure if you can perform your desired experiment in a single lane? The table below provides an overview of analyte compatibility:
Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler
Breast cancer is a heterogenous disease with variability in tumor cells and in the surrounding tumor microenvironment (TME). Understanding the molecular diversity in breast cancer is critical for improving prediction of therapeutic response and prognostication.
Spatially organized multicellular immune hubs in human colorectal cancer.
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals.
Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma.
Histiocytic sarcoma (HS) is a rare and aggressive tumor in humans with no universally agreed standard of care therapy. Spontaneous canine HS exhibits increased prevalence in specific breeds, shares key genetic and biologic similarities with the human disease, and occurs in an immunocompetent setting.