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nCounter®
Tumor Signaling 360™ Panel

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Helping Your Research

As therapeutics that target tumor signaling evolve, a greater understanding of tumor signaling is required as well as a better understanding of the interactions of tumor cells with the tissue milieu. The Tumor Signaling 360 Panel is intended to play this exact role, enabling deeper profiling of the tumor that is complete, yet focused on signaling pathways of interest for targeted therapeutic development. Covering hundreds of genes involved in tumorigenesis, metastasis, and inflammation, the nCounter Tumor Signaling 360 Panel offers a holistic view of the biology of the tumor, microenvironment, and immune response with an emphasis on dysfunctional cell signaling in cancer.

  • Profile 40+ pathways involved in tumor biology, immune evasion, and remodeling of the microenvironment.
  • Identify targets for novel therapeutics
  • Understand the mechanism of action of targeted therapies
  • Determine the extent of anti-tumor immune response with the Tumor Inflammation Signature
  • Quantify the presence and relative abundance of 14 different immune cell types

Inspired by systems biology approaches to cancer research, NanoString’s 360 Series Panel Collection gives you a 360° view of gene expression by combining carefully-curated content involved in the biology of the tumor, microenvironment, and the immune response into a single holistic assay. Each panel contains the 18-gene Tumor Inflammation Signature (TIS) that measures a peripherally-suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.

tumor promotion inflammation illustration

How it Works

The nCounter 360 series of cancer gene expression panels have been developed to comprehensively profile the tumor, immune response, and microenvironment. Genes included in the Tumor Signaling 360 Panel are organized and linked to various advanced analysis modules to allow for efficient analysis of cell signaling pathways.

Advanced Analysis Modules available for Tumor Signaling 360:

  • Normalization
  • Quality Control
  • Individual Pathway Analysis
  • Cell Profiling
  • Differential Expression
  • Gene Set Analysis
  • Built-in compatibility for Panel-Plus and Protein Analysis

 

Panel Selection Tool

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Product Information

Core Themes and Annotations
Tumor Inflammation Signature
Immune Cell Type Gene Coverage
Product Specifications
Catalog Information
Product Comparison
Core Themes and Annotations
Tumor Inflammation Signature

The Tumor Inflammation Signature includes 18 functional genes known to be associated with response to PD-1/PD-L1 inhibitors.

Includes four areas of Immune Biology: IFN-ү-responsive genes related to antigen presentation, chemokine expression, cytotoxic activity, and adaptive immune resistance genes.

The tumor inflammation gene expression signature highlights the complex biology of the host immune microenvironment.

View publication and video.

  1. Ayers, Mark, et al. “IFN-y-related mRNA profile predicts clinical response to PD-1 blockade.” The Journal of Clinical Investigation 127.8 (2017).
Immune Cell Type Gene Coverage

Platform Specifications (*Does not apply to Prosigna® Breast Cancer Prognostic Gene Signature Assay (1))

Product Specifications
Catalog Information
Product Comparison

360 Series Product Comparison

Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.

Related Resources

See All Resources
Product Bulletin Tumor Signaling 360 Panel – Product Bulletin
Blog Cancer Immunotherapy at SITC 2019: The Good, the Bad and the Solution
Blog How the Field of Immuno-Oncology is Changing Fast
Blog From an Egyptian Papyrus to the Hallmarks of Cancer: A Journey through the Development of Knowledge in Oncology Research

Publications

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A novel diagnostic approach for the classification of small B-cell lymphoid neoplasms based on the NanoString platform.

Small B-cell lymphoid neoplasms (SBCLNs) are a heterogeneous group of diseases characterized by malignant clonal proliferation of mature B-cells. However, the classification of SBCLNs remains a challenge, especially in cases where histopathological analysis is unavailable or those with atypical laboratory findings or equivocal pathologic data.

Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade.

BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1.

Expression of CIB1 correlates with colorectal liver metastases but not with peritoneal carcinomatosis.

Background: Molecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic spread thus it is imperative to understand its key drivers to develop biomarkers for risk stratification, follow-up protocols and personalized therapy.

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