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nCounter®
PanCancer Progression Panel

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Helping Your Research

Cancer progression involves multiple processes and mechanisms that are highly interconnected. The nCounter PanCancer Progression Panel lets you perform multiplex gene expression analysis with 770 genes from each step in the cancer progression process including: angiogenesis, extracellular matrix remodeling (ECM), epithelial-to-mesenchymal transition (EMT) and metastasis. 

  • Comprehensive gene expression analysis of cancer progression 
  • Quantify gene expression of metastatic growth and suppressor genes 
  • Rapidly and easily screen samples for biomarker discovery or drug mechanism of action to support your research 
  • Customizable with up to 55 additional user-defined genes with Panel Plus option 
  • 3D-enabled for multi-analyte analysis with Vantage 3D™ Assays

Inspired by systems biology approaches to cancer research, NanoString’s 360 Series Panel Collection gives you a 360° view of gene expression by combining carefully-curated content involved in the biology of the tumor, microenvironment, and the immune response into a single holistic assay. Each panel contains the 18-gene Tumor Inflammation Signature (TIS) that measures a peripherally-suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.

How It Works

Progression Panel Gene Coverage

The following is a pictorial description of the processes and key genes included in the PanCancer Progression Panel

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

Specifications
Catalog Information
Product Comparison
Specifications
Catalog Information
Product Comparison

360 Series Product Comparison

Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.

Related Resources

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Product Bulletin Hallmarks of Cancer – Product Bulletin
Supplement Hallmarks of Cancer Supplement
Whitepaper Multiplexed Cancer Progression Analysis – Whitepaper

Publications

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A novel diagnostic approach for the classification of small B-cell lymphoid neoplasms based on the NanoString platform.

Small B-cell lymphoid neoplasms (SBCLNs) are a heterogeneous group of diseases characterized by malignant clonal proliferation of mature B-cells. However, the classification of SBCLNs remains a challenge, especially in cases where histopathological analysis is unavailable or those with atypical laboratory findings or equivocal pathologic data.

Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade.

BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1.

Expression of CIB1 correlates with colorectal liver metastases but not with peritoneal carcinomatosis.

Background: Molecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic spread thus it is imperative to understand its key drivers to develop biomarkers for risk stratification, follow-up protocols and personalized therapy.

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