Immune Profiling Panel
Helping Your Research
Gene expression profiling an be challenging because reproducibility and data analysis can be extremely demanding. The nCounter PanCancer Pathways Panel offers fast and high-throughput multiplex gene expression analysis solution for human or mouse genes. Each panel comes with 770 genes from 13 cancer-associated canonical pathways to support the understanding of basic cancer biology.
Inspired by systems biology approaches to cancer research, NanoString’s 360 Series Panel Collection gives you a 360° view of gene expression by combining carefully-curated content involved in the biology of the tumor, microenvironment, and the immune response into a single holistic assay. Each panel contains the 18-gene Tumor Inflammation Signature (TIS) that measures a peripherally-suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.
How It Works
Perform multiplex gene expression analysis in human or mouse with 770 genes from 14 different immune cell types, common checkpoint inhibitors, and genes covering both the adaptive and innate immune response. The panel measures many features of the immune response to facilitate rapid development of clinically actionable gene expression profiles in the context of cancer immunotherapy.
Comprehensive profiling of the immune response optimized for immuno-oncology research
Identify tumor-infiltrating lymphocytes (TILs) for the tumor microenvironment
Profile the expression of 30 CT antigens in humans
Assess mechanistic pathway activity for single or combination studies
Customizable with up to 55 additional user-defined genes with Panel Plus option
Multi-analyte analysis with Vantage 3D™ Assays
The nCounter PanCancer Immune Profiling Panel is for cancer researchers that need more markers than is practical for RT-qPCR but don’t want the broad approach that next-gen sequencing (NGS) offers. The Panel is fully compatible with clinically relevant sample types such as fresh-frozen (FF) tissue, formalin-fixed, paraffin-embedded (FFPE) tumor sections, isolated immune cell populations such as PBMCs, and cell lysates. The panel may be used in conjunction with nCounter Panel Plus products for additional flexibility in experimental design.
Panel Selection Tool
Find the gene expression panel for your research with easy to use panel proFind Your Panel
360 Series Product Comparison
Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.
Spatially resolved transcriptomics and its applications in cancer
Spatially resolved transcriptomics (SRT) offers the promise of understanding cells and their modes of dysfunction in the context of intact tissues. Technologies for SRT have advanced rapidly with a large number being published in recent years.
NUPR1 is a critical repressor of ferroptosis.
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive.
Predictive Value of Circulating miRNAs in Lymph Node Metastasis for Colon Cancer.
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