nCounter® Metabolic Pathways Panel

Helping Your Research

Quantify the expression of hundreds of genes involved in core metabolic processes and immunometabolism for human or mouse samples in a reliable, simple, and robust way using the nCounter Metabolic Pathways Panel. Understand the complex mechanisms behind metabolic adaptation, metabolic switching, metabolic alterations, and study changes in mitochondrial respiration and glycolysis.

The Metabolic Pathways Panel helps advance efforts towards novel therapeutic targets that take advantage of altered metabolism in cancer and other diseases. Get results in less than 24 hours from multiple sample types with a workflow that maximizes insight and minimizes turnaround time:

Quantify the presence and relative abundance of 14 different immune cell types for immunometabolism studies
Bypass RT and amplification by direct detection, yielding highly reproducible data
Process your samples with < 30 minutes hands-on time and get results in < 24 hours
Receive publication-ready figures with off-the-shelf data analysis with nSolver™ Data Analysis Software

How It Works

The underlying molecular mechanisms behind alterations in metabolic pathways, signaling pathways, and cell stress can now be fully elucidated, giving you a complementary tool to traditional metabolite assays for profiling metabolic checkpoints and potential therapeutic targets.

Directly profile 768 genes in human or mouse across 34 annotated pathways involved in five important themes for metabolism research:

01:

Biosynthesis and Anabolic Pathways

02:

Nutrient Capture and Catabolic Pathways

03:

Cell Stress

04:

Metabolic Signaling

05:

Transcriptional Regulation

Publications

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Spatially resolved transcriptomics and its applications in cancer

Spatially resolved transcriptomics (SRT) offers the promise of understanding cells and their modes of dysfunction in the context of intact tissues. Technologies for SRT have advanced rapidly with a large number being published in recent years.

NUPR1 is a critical repressor of ferroptosis.

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive.

Predictive Value of Circulating miRNAs in Lymph Node Metastasis for Colon Cancer.

(1) Background: Lymph node (LN) status is an indubitable prognostic factor for survival among colon cancer patients. MicroRNAs (miRNAs) have been implicated in the development and progression of many cancers and are potential biomarkers for cancer diagnosis and prognosis.