nCounter® Breast Cancer 360™

Helping Your Research

Want a system that provides a unique 360° view of gene expression for the breast tumor, microenvironment, and immune response? If yes, then you have found the right product. The Human nCounter Breast Cancer 360 panel and data analysis report helps researchers quickly decode the complexities of breast cancer biology, develop novel breast cancer gene signatures, and categorize disease heterogeneity using 48 biological signatures including signatures based upon the validated PAM50 and Tumor Inflammation Signature (TIS) assays. Get the most out of your panel by quickly distilling a large amount of data into actionable signatures measuring variables crucial to breast tumor-immune interaction.

How It Works

The content included in the Breast Cancer 360 panel allows for a more comprehensive measurement of biological variables crucial to tumor progression and response to a wide range of treatments. Research signatures are enriched with potentially predictive genes involved in proliferation, endothelial, angiogenesis, cytotoxicity, stroma, inflammatory chemokines, and apoptosis.

01:

Highly Curated Content:

Expertly curated, comprehensive content includes 776 genes across 23 key breast cancer pathways and processes, 10 research focused signatures and 30 novel signatures measuring important tumor and immune activities.

02:

Comprehensive Coverage:

Expanded evaluation of breast cancer subtypes including: PAM50 Signature, TNBC, and Claudin-Low Signature.

03:

Interactive, Flexible Report:

The Interactive Breast Cancer 360 data analysis report provides insight into 48 signatures across 13 categories measuring biological variables crucial to breast cancer tumor biology.

You can access validated signatures like PAM50, Tumor Inflammation Signature (TIS), Risk of Recurrence (ROR)/Genomic Risk. Analyze your data by survival, response or grouping variables, or drill down into individual sample variability. Analyze clinical variables by TNBC/PAM50 subtype or variables of your choosing.

04:

Publication Ready Data:

The report generates figures, statistical outputs, methods for your publication, or poster presentation.

Hear more about Breast Cancer 360 panel from our scientists- Video Decode Heterogeneity with the Breast Cancer 360™ Panel

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Product Information

Breast Cancer 360 Biological Signatures

Breast Cancer 360 Pathways and Processes

PAM50 and TIS Signatures

Product Specifications

Breast Cancer 360 Biological Signatures

Breast Cancer 360 Pathways and Processes

Includes expertly curated 776 genes across 23 categories of breast cancer tumor biology to support the evaluation of pathways and process, as well as novel signature development.

PAM50 and TIS Signatures

Content included in the Breast Cancer 360 panel allows for a more comprehensive measurement of biological variables crucial to tumor progression and response to a wide-range of treatments. Research signatures are enriched with potentially predictive genes involved in proliferation, endothelial, angiogenesis, cytotoxicity, stroma, inflammatory chemokines, and apoptosis.

48 signatures including two analytically validated signatures- PAM50^1,2 and Tumor Inflammation Signature³
10 research-focused signatures and 30 novel signatures measuring important tumor and immune activities
adapted to decode breast cancer biology in concert

Analytically Validated Signatures

PAM50 Signature^1,2

Included with the Breast Cancer 360 panel is the PAM50 Signature. This 50-gene signature measures a gene expression profile that allows for the classification of breast cancer into four biologically distinct subtypes and a prognostic score.

PAM50 Subtype
- Luminal A
- Luminal B
- HER2-Enriched
- Basal-like
Prosigna Score / Risk of Recurrence

Tumor Inflammation Signature³

Included with the Breast Cancer 360 panel is the Tumor Inflammation Signature. This 18-gene signature measures activity known to be associated with response to PD-1/PD-L1 inhibitors pathway blockade³.

Includes 4 areas of immune biology used to determine peripherally suppressed immune response and the identification of “hot” or “cold” tumors
- Antigen Presenting Cells
- T Cell/NK presence
- IFNγ Biology
- T Cell Exhaustion
Tissue-of-origin agnostic (Pan-cancer)
Potential surrogate for PD-L1 and mutational load in research setting⁴