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nCounter® Neuroinflammation Panel

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Helping Your Research

Neuroinflammation research today requires a broad view of all the underlying aspects of neurological disorders and injury, including an assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism. The nCounter Neuroinflammation Panels support and simplify your neuroinflammation research needs by providing a complete view of the complex interplay between the immune system and the Central Nervous System (CNS). These panels deliver a comprehensive evaluation of the pathways, processes, and cell types that are involved in neuroinflammation. Product highlights include:

  • Gene expression profiling of neuroimmune interactions 
  • The study of drug treatment response and signature generation 
  • Biomarker characterization
  • Research of neurodegenerative disease, traumatic brain injury, psychiatric disorders, neuropathic pain, CNS infection, and others 
Neuroinflammation brain illustration

How It Works

The Neuroinflammation Panels are based on the nCounter barcoding technology that allows for direct quantification of hundreds of transcripts with an automated platform that requires minimal hands-on time. Complete your projects in record time by spending less time on sample prep and more time getting insights from data that can be analyzed in minutes with the nSolver™ Analysis Software or ROSALIND. These panels include 770 genes for human and mouse studies on inflammation of the CNS.

01:

Comprehensively assess 23 neuroinflammation pathways and processes

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Measure the relative abundance of 5 CNS cell types and 14 peripheral immune cell types with the unique cell profiling feature

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Customizable with Panel Plus option – add up to 55 genes of your choice

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Use only 15 minutes hands-on time to set up the streamlined, user-friendly, and efficient nCounter workflow

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

CNS and Peripheral Immune Cell Profiling
Immunity and Inflammation
Neurobiology and Neuropathology
Metabolism and Stress
Product Specifications
Catalog Information
CNS and Peripheral Immune Cell Profiling

Genes included in the Neuroinflammation Panels provide unique cell profiling data for measuring the relative abundance of 5 CNS and 14 peripheral immune cell types in a single sample1. The table below summarizes each cell type represented by gene content in the panel qualified through biostatistical approaches and selected literature in the field of neuroinflammation research.

1Danaher P. et al. Gene expression markers of Tumor Infiltrating Leukocytes JITC 2017

Immunity and Inflammation

Functional annotations for 23 pathways and processes were assigned across the genes in the Neuroinflammation Panels. The 23 pathways and processes represent three core themes of neuroinflammation: immunity and inflammation, neurobiology and neuropathology, and metabolism and stress.

The role of innate immunity in many neurological disorders is now widely accepted in the research world although the relative contributions of these processes to the progression and/or amelioration of these diseases is incompletely understood. Several key processes and pathways are assessed in this panel to provide a comprehensive view of the immune and inflammatory response in the nervous system.

Neurobiology and Neuropathology

Neuropathology research today requires a broad view of all the underlying aspects of neurological disorders and injury, including an assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism. There are 13 pathways and processes included in this panel to evaluate the impact of neuroinflammation and immune actions in the nervous system on neuropathology.

Metabolism and Stress

Metabolic dysfunction and stress have been shown to influence brain activity and disrupt CNS homeostasis and cognitive function by adopting neurotoxic functions. The genes selected for this panel are designed to assess important aspects of metabolism and stress that are known to impact neuroinflammation.

Product Specifications
Catalog Information

Related Resources

See All Resouces
Product Bulletin nCounter Neuroinflammation Panel – Product Bulletin
Whitepaper Neuro Pub Review – Whitepaper
Blog Researcher Profiles: How NanoString® Neuroscience Grant Program Winners are Utilizing nCounter® Technology
Blog Advancing Neuroscience Gene Expression Research

Retrospective Validation of a 168-Gene Expression Signature for Glioma Classification on a Single Molecule Counting Platform.

Gene expression profiling has been shown to be comparable to other molecular methods for glioma classification. We sought to validate a gene-expression based glioma classification method.

Supratentorial ependymoma in childhood: more than just RELA or YAP.

Two distinct genetically defined entities of ependymoma arising in the supratentorial compartment are characterized by the presence of either a C11orf95-RELA or a YAP-MAMLD1 fusion, respectively. There is growing evidence that supratentorial ependymomas without these genetic features exist.

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits.

Background: Disruptions of brain-gut axis have been implicated in the progression of a variety of gastrointestinal (GI) disorders and central nervous system (CNS) diseases and injuries, including traumatic brain injury (TBI). TBI is a chronic disease process characterized by persistent secondary injury processes which can be exacerbated by subsequent challenges.

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