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nCounter® Host Response Panel

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Helping Your Research

Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics to fight infectious disease.  The nCounter® Host Response Panel helps researchers study the phases and progression of infection across the major components of the host response with pathogen-agnostic content optimized for blood, but suitable for all sample types. The panel was specifically developed for understanding the complexities of the immune response to infectious disease, including COVID-19. 

The Host Response Panel helps rapidly advance knowledge of emerging infectious disease with experiments that take minutes to setup and get you results in less than 24 hours. 

  • Study the five elements of the host response 
    • Host Susceptibility 
    • Interferon Response 
    • Innate Immune Cell Activation 
    • Adaptive Immune Response 
    • Homeostasis 
  • Profile 785 human genes across 50+ pathways  
  • Detect the presence of a pathogen and evaluate organ-specific tissue damage with a Panel-Plus spike-in of up to 55 genes 
  • Develop signatures of host response dynamics 
  • Identify and validate biomarkers for disease severity 
  • Evaluate the effect of vaccines & therapies 

Get off-the-shelf data analysis and publication-ready figures with the nSolver™ Analysis Software.

nCounter host response

Biological Framework of the Host Response Panel

How it Works

Panel Customization
Panel Customization

Customize your research project by adding tissue or pathogen-specific probes to the Host Response Panel with a 55-gene Panel Plus. Add the off-the-shelf 20-gene Coronavirus Panel Plus to study SARS-CoV-2 and other coronaviruses or build your own Panel Plus gene list with transcripts specific for different tissue types. Mix and match transcripts from the pathogen of your choice and additional host tissue markers to add a Panel Plus to the Host Response Panel for studying the pathogenesis of various infectious diseases.

Safety and Tolerability of Bacteriophage Therapy in Severe Staphylococcus aureus Infection

The UzcRS two‐component system in Caulobacter crescentus integrates regulatory input from diverse auxiliary regulators

PPARγ is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis

Product Information

Resources
Product Specifications
Signatures/ Pathways
Immune Checkpoint Coverage
NHP Compatibility
Immune Cell Type Profiling Gene Coverage
Product Specifications
Signatures/ Pathways
Immune Checkpoint Coverage

Take advantage of comprehensive coverage of the most relevant immune checkpoints to study modulation of the host immune response and subsequent inflammatory cascade. 

NHP Compatibility

Probes included in the Host Response Panel have high homology to non-human primates, allowing for seamless comparative infectious disease research as well as preclinical studies. Percent identity is used to estimate likelihood of the probe functioning on non-human primate targets. Additional comparisons with other NHP species are available upon request. 

Immune Cell Type Profiling Gene Coverage

Genes included in the Host Response Panel provide unique cell profiling data to measure the relative abundance of 14 different immune cell types. The table below summarizes the genes included in each cell type signature, as qualified through biostatistical approaches and selected literature in the field.

Support Documents

Study organ damage wrought by COVID-19 by adding up to 55 genes to the Host Response Panel as a Panel Plus or by adding custom targets to a GeoMx® Digital Spatial Profiling RNA assay.  

Thee COVID-19 Tissue Reference Gene List can be used to get ideas on which genes to add for studying the effect of COVID-19 on the kidney, GI tract, heart, liver, endothelium, lung, and brain. The content is mined from publications and represents genes associated multiple times in the literature as related to a tissue in the context of COVID-19, as well as the top ten genes associated with that tissue. The rationale for each gene’s inclusion and its presence or absence in the Host Response Panel and the GeoMx COVID-19 Immune Response Atlas is noted.  

Listed genes can be used alongside any nCounter gene expression panel or GeoMx RNA assay; please contact Bioinformatics for more information on which genes may already be present in a given panel or GeoMx RNA assay of interest.  Check back often for updates as the NanoString Bioinformatics team continually adds to and refines these reference gene lists. 

Skysphere

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