nCounter® Viral Panel Plus Menu
Helping Your Research
There are many applications in infectious disease research where viral detection is useful, such as understanding how the viral life cycle affects the host response, disease pathogenesis, the impact of antivirals and vaccines, and chronic infection. It can be difficult with RNA sequencing to detect viral transcripts in infected samples due to the overwhelming amount of host material present.
How it Works
The targeted and customizable nature of nCounter technology makes it easy to profile transcripts from the host and one or more pathogens simultaneously. Probes for pathogens can be added as a Panel Plus spike-in to an off-the-shelf human or mouse Gene Expression Panel or included in a de novo Custom CodeSet. The nCounter Viral Panel Plus Menu is a list of pre-designed Research Use Only probes for eight viruses associated with chronic disease and/or cancer. You can use the pre-designed probes as is in a Panel Plus design or mix and match probes from different viruses to create your own Panel Plus of choice. Probes were designed to cover as many sequences as possible while at the same time ensuring sensitivity, specificity, and breadth of coverage.
Probes cannot be used in a standalone assay and must be paired with an nCounter Gene Expression Panel. Check with bioinformatics about compatibility with a specific panel; however, the Viral Panel Plus Menu has been designed to be compatible with most nCounter panels. Probes are also compatible with Elements™ chemistry and PlexSet™ assays. Viral detection may differ across different sample types.
For ideal coverage of the host response to a particular virus, pair the Viral Panel Plus Menu probes with the Host Response Panel or study the effect of chronic viral infections on T cell, B cell, and NK cell function with the Immune Exhaustion Panel.
Panel Selection Tool
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Spatially organized multicellular immune hubs in human colorectal cancer.
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals.
Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma.
Histiocytic sarcoma (HS) is a rare and aggressive tumor in humans with no universally agreed standard of care therapy. Spontaneous canine HS exhibits increased prevalence in specific breeds, shares key genetic and biologic similarities with the human disease, and occurs in an immunocompetent setting.