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nCounter® Viral Panel Plus Menu

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Helping Your Research

There are many applications in infectious disease research where viral detection is useful, such as understanding how the viral life cycle affects the host response, disease pathogenesis, the impact of antivirals and vaccines, and chronic infection.  It can be difficult with RNA sequencing to detect viral transcripts in infected samples due to the overwhelming amount of host material present.

How it Works

Viral Pathogenesis Made Easy
Biological Framework
Viral Panel Plus Menu
Viral Pathogenesis Made Easy

The targeted and customizable nature of nCounter technology makes it easy to profile transcripts from the host and one or more pathogens simultaneously. Probes for pathogens can be added as a Panel Plus spike-in to an off-the-shelf human or mouse Gene Expression Panel or included in a de novo Custom CodeSet. The nCounter Viral Panel Plus Menu is a list of pre-designed Research Use Only probes for eight viruses associated with chronic disease and/or cancer. You can use the pre-designed probes as is in a Panel Plus design or mix and match probes from different viruses to create your own Panel Plus of choice. Probes were designed to cover as many sequences as possible while at the same time ensuring sensitivity, specificity, and breadth of coverage.
Probes cannot be used in a standalone assay and must be paired with an nCounter Gene Expression Panel. Check with bioinformatics about compatibility with a specific panel; however, the Viral Panel Plus Menu has been designed to be compatible with most nCounter panels. Probes are also compatible with Elements™ chemistry and PlexSet™ assays. Viral detection may differ across different sample types.

Biological Framework

For ideal coverage of the host response to a particular virus, pair the Viral Panel Plus Menu probes with the Host Response Panel or study the effect of chronic viral infections on T cell, B cell, and NK cell function with the Immune Exhaustion Panel.

Viral Panel Plus Menu

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Related Resources

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Blog COVID-19 Pathogenesis Steps Out of the Shadows
Webinar COVID-19 One Year Later: A Host Response Symposium
Whitepaper Infectious Disease – Whitepaper
Product Bulletin Host Response Panel – Product Bulletin
Product Bulletin Immune Exhaustion – Product Bulletin

Publications

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Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade.

BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1.

Gene expression of oxidative stress markers and lung function: A CARDIA lung study.

BACKGROUND: Circulating markers of oxidative stress have been associated with lower lung function. Our objective was to study the association of gene expression levels of oxidative stress pathway genes (ALOX12, ALOX15, ARG2, GSTT1, LPO, MPO, NDUFB3, PLA2G7, and SOD3) and lung function forced expiratory volume in one second (FEV1 ), forced vital capacity (FVC) in Coronary Artery Risk Development in Young Adults study.

Circadian dynamics of the teleost skin immune-microbiome interface.

Background: Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised.

Skysphere

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