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nCounter® NHP Immunology Panel

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Helping Your Research

Non-Human Primate (NHP) research is critical to provide insight into the functionality of drugs and vaccines in development. Studies with NHPs are costly and produce a plethora of samples: extracting the maximal biological information out of a given sample in a cost-effective and robust manner becomes key.  NanoString’s nCounter barcoding technology provides an ideal solution; you can directly quantify hundreds of transcripts from multiple sample types with minimal hands-on time, and the data is very reproducible.

Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques

How It Works

The nCounter NHP Immunology Panel runs on the nCounter® Analysis System and utilizes the easy to use nSolver™ Analysis Software or the cloud-based ROSALIND by OnRamp Bio for doing differential gene expression studies. The NHP Immunology Panel includes 770 key immune response genes that encompass 18 immune-related signaling pathways. Panel genes and probes cover the top 3 NHP species (Rhesus Macaque, Cynomolgus Macaque, and Green Monkey).

Hightlights:

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Ideal for vaccine development, transplant research, immuno-oncology, toxicology and other research areas

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Isoform coverage for the top four species of NHP

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All genes are selected from conserved human regions to achieve nearly 100% cross-reactivity in human

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Customizable with the Panel Plus option – add up to 55 user-defined genes

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nCounter workflow is simple, user-friendly, and efficient with just 15 minutes total hands-on time

Panel Selection Tool

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Product Information

NHP Immunology Gene Content
Product Specifications
Catalog Information
NHP Immunology Gene Content

Functional annotations for 18 immune-related signaling pathways were assigned across all genes in the NHP Immunology panel, allowing for a comprehensive and functional view of the NHP immune response.

Product Specifications
Catalog Information

Related Resources

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Whitepaper Critical Role of Nonhuman Primates in Medical Research – Whitepaper

Publications

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Host response transcriptomic analysis of Crimean-Congo hemorrhagic fever pathogenesis in the cynomolgus macaque model.

Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne RNA virus prevalent in Asia, Europe, and Africa, and can cause a hemorrhagic disease (CCHF) in humans with mortality rates as high as 60%. A general lack of both effective medical countermeasures and a comprehensive understanding of disease pathogenesis is partly driven by an historical lack of viable CCHF animal models.

Bundibugyo ebolavirus Survival Is Associated with Early Activation of Adaptive Immunity and Reduced Myeloid-Derived Suppressor Cell Signaling.

Ebolaviruses Bundibugyo virus (BDBV) and Ebola virus (EBOV) cause fatal hemorrhagic disease in humans and nonhuman primates. While the host response to EBOV is well characterized, less is known about BDBV infection.

Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model.

Ebola virus is a continuing threat to human populations, causing a virulent hemorrhagic fever disease characterized by dysregulation of both the innate and adaptive host immune responses. Severe cases are distinguished by an early, elevated pro-inflammatory response followed by a pronounced lymphopenia with B and T cells unable to mount an effective anti-viral response.

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