nCounter® NHP Immunology Panel
Helping Your Research
Non-Human Primate (NHP) research is critical to provide insight into the functionality of drugs and vaccines in development. Studies with NHPs are costly and produce a plethora of samples: extracting the maximal biological information out of a given sample in a cost-effective and robust manner becomes key. NanoString’s nCounter barcoding technology provides an ideal solution; you can directly quantify hundreds of transcripts from multiple sample types with minimal hands-on time, and the data is very reproducible.
Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques
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Product Information
Functional annotations for 18 immune-related signaling pathways were assigned across all genes in the NHP Immunology panel, allowing for a comprehensive and functional view of the NHP immune response.
Publications
Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model.
Ebola virus is a continuing threat to human populations, causing a virulent hemorrhagic fever disease characterized by dysregulation of both the innate and adaptive host immune responses. Severe cases are distinguished by an early, elevated pro-inflammatory response followed by a pronounced lymphopenia with B and T cells unable to mount an effective anti-viral response.
Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates
Invasive bacterial infections during pregnancy are a major risk factor for preterm birth, stillbirth, and fetal injury. Group B streptococci (GBS) are Gram-positive bacteria that asymptomatically colonize the lower genital tract but infect the amniotic fluid and induce preterm birth or stillbirth.
Innate Immune Responses to Chimpanzee Adenovirus Vector 155 Vaccination in Mice and Monkeys.
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