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nCounter® Metabolic Pathways Panel

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Helping Your Research

Quantify the expression of hundreds of genes involved in core metabolic processes and immunometabolism for human or mouse samples in a reliable, simple, and robust way using the nCounter Metabolic Pathways Panel. Understand the complex mechanisms behind metabolic adaptation, metabolic switching, metabolic alterations, and study changes in mitochondrial respiration and glycolysis.

The Metabolic Pathways Panel helps advance efforts towards novel therapeutic targets that take advantage of altered metabolism in cancer and other diseases. Get results in less than 24 hours from multiple sample types with a workflow that maximizes insight and minimizes turnaround time:

  • Quantify the presence and relative abundance of 14 different immune cell types for immunometabolism studies
  • Bypass RT and amplification by direct detection, yielding highly reproducible data
  • Process your samples with < 30 minutes hands-on time and get results in < 24 hours

How It Works

The underlying molecular mechanisms behind alterations in metabolic pathways, signaling pathways, and cell stress can now be fully elucidated, giving you a complementary tool to traditional metabolite assays for profiling metabolic checkpoints and potential therapeutic targets.

Directly profile 768 genes in human or mouse across 34 annotated pathways involved in five important themes for metabolism research:

01:

Biosynthesis and Anabolic Pathways

02:

Nutrient Capture and Catabolic Pathways

03:

Cell Stress

04:

Metabolic Signaling

05:

Transcriptional Regulation

Panel Selection Tool

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Product Information

Gene Coverage Across Core Metabolic Themes
Functional Annotations
Immune Cell Profiling
Product Specifications
Catalog Information
Gene Coverage Across Core Metabolic Themes
Functional Annotations
Immune Cell Profiling
Product Specifications
Catalog Information

Related Resources

See All Resources
Product Bulletin Metabolic Pathways Panel – Product Bulletin
Blog Q&A with Metabolic Pathways Panel Grant Winner Teresa Cardoso Delgado, Ph.D.: The Metabolomics of Non-Alcoholic Fatty Liver Disease (NAFLD)
Webinar Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
Webinar Hepatic transcriptional profiling in mouse models of Non-Alcoholic Fatty Liver Disease (NAFLD)

Publications

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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma.

Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine metabolism, with high-dose methotrexate.

Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation.

Recent studies suggest that metabolic regulation may improve differentiation of cardiomyocytes derived from induced pluripotent stem cells (iPSCs). AMP-activated protein kinase (AMPK) is a master regulator of metabolic activities.

High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery.

Esophageal adenocarcinoma (EAC) is a highly heterogeneous disease, dominated by large-scale genomic rearrangements and copy number alterations. Such characteristics have hampered conventional target-directed drug discovery and personalized medicine strategies, contributing to poor outcomes for patients.

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