Masthead

nCounter® Human Organ Transplant Panel

Masthead

Are you looking to develop signatures pre- and post-organ transplant to help determine risk of rejection? Then the nCounter Human Organ Transplant Panel is the research tool for you.

Helping Your Research

Panel Development

The Human Organ Transplant Panel was created through a collaboration between NanoString and the Banff Foundation for Allograft Pathology, a global consortium of researchers from multiple prestigious institutes, including researchers from the University of AlbertaErasmus Medical Center RotterdamImperial College LondonMassachusetts General HospitalUniversity of Oxford, and the Paris Transplant Group. The consortium aims to improve organ transplant outcomes through advanced molecular characterization of the in-situ response in the allograft and to make available a transformational new approach for research that can be used to accelerate the identification of new biomarkers of rejection, uncover the mechanisms behind tissue damage, and monitor toxicities brought on by immunosuppressive drugs and infections.

Banff 2019 Meeting Report

Read the Banff 2019 Meeting Report  to learn more about how the content for the Human Organ Transplant panel was created and how the Banff Molecular Diagnostics Working Group (MDWG) plans to maximize data collected using the panel through the formation of a consortium and access to a shared database.

nCounter Human Organ Transplant Panel

How it Works

You can comprehensively profile 770 genes across 37 pathways to identify biomarkers for rejection, uncover the mechanisms of tissue damage, and study toxicities brought on by immunosuppressive drugs.

01:

Study the immune response to transplanted tissue

02:

Discover biomarkers for organ rejection and tissue damage for kidney, heart, liver, and lung

03:

Evaluate immunosuppressive drug pathways

04:

Understand mechanisms behind drug-induced toxicity

05:

Identify BK Polyomavirus, Cytomegalovirus, and Epstein-Barr virus

06:

Quantify the relative abundance of 14 different immune cells

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

Find Your Panel

Product Information

Functional Annotations
Viral Identification
NHP Compatibility
Product Specifications
Catalog Information
Functional Annotations
Viral Identification

Solid organ and hematopoietic transplant recipients are at increased risk for developing complications from opportunistic viral infections and may even inherit a viral infection from the donor. Knowing if a viral infection is present can be essential to understanding both the immune response and the potential impact of immunosuppressive treatments. Included in the Human Organ Transplant panel are probes specific for the detection of BK Polyomavirus, Cytomegalovirus (CMV) and Epstein-Barr virus (EBV).

NHP Compatibility

Probes included in the Human Organ Transplant Panel have been confirmed to also have high homology to non-human primates providing a valuable tool for translational comparative studies using both human and non-human samples.

Product Specifications
Catalog Information

Related Resources

View All Resources
Product Bulletin Human Organ Transplant Panel – Product Bulletin
Blog Molecular Signatures of Antibody-Mediated Rejection and Graft Outcome After Kidney Transplantation. Q&A with Dr. Dela Golshayan, M.D., Ph.D.
Blog Solid Organ Transplantation and the Immunology of Rejection. Q&A with GeoMx® Digital Spatial Profiler Grant Winner Dr. Fadi Issa
Blog The bench side of organ transplant: Challenges and solutions
Blog Searching for New Biomarkers to Prevent Organ Transplant Rejection. Q&A with HOT Panel Grant Winner Dr. Evan Farkash

Publications

View All Publications

Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade.

BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1.

Gene expression of oxidative stress markers and lung function: A CARDIA lung study.

BACKGROUND: Circulating markers of oxidative stress have been associated with lower lung function. Our objective was to study the association of gene expression levels of oxidative stress pathway genes (ALOX12, ALOX15, ARG2, GSTT1, LPO, MPO, NDUFB3, PLA2G7, and SOD3) and lung function forced expiratory volume in one second (FEV1 ), forced vital capacity (FVC) in Coronary Artery Risk Development in Young Adults study.

Circadian dynamics of the teleost skin immune-microbiome interface.

Background: Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised.

Skysphere

Contact Us

Have questions or simply want to learn more?

Contact our helpful experts and we’ll be in touch soon.

Contact Us