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nCounter® Human Organ Transplant Panel

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Are you looking to develop signatures pre- and post-organ transplant to help determine risk of rejection? Then the nCounter Human Organ Transplant Panel is the research tool for you.

Helping Your Research

Panel Development

The Human Organ Transplant Panel was created through a collaboration between NanoString and the Banff Foundation for Allograft Pathology, a global consortium of researchers from multiple prestigious institutes, including researchers from the University of AlbertaErasmus Medical Center RotterdamImperial College LondonMassachusetts General HospitalUniversity of Oxford, and the Paris Transplant Group. The consortium aims to improve organ transplant outcomes through advanced molecular characterization of the in-situ response in the allograft and to make available a transformational new approach for research that can be used to accelerate the identification of new biomarkers of rejection, uncover the mechanisms behind tissue damage, and monitor toxicities brought on by immunosuppressive drugs and infections.

Banff 2019 Meeting Report

Read the Banff 2019 Meeting Report  to learn more about how the content for the Human Organ Transplant panel was created and how the Banff Molecular Diagnostics Working Group (MDWG) plans to maximize data collected using the panel through the formation of a consortium and access to a shared database.

nCounter Human Organ Transplant Panel

How it Works

You can comprehensively profile 770 genes across 37 pathways to identify biomarkers for rejection, uncover the mechanisms of tissue damage, and study toxicities brought on by immunosuppressive drugs.

01:

Study the immune response to transplanted tissue

02:

Discover biomarkers for organ rejection and tissue damage for kidney, heart, liver, and lung

03:

Evaluate immunosuppressive drug pathways

04:

Understand mechanisms behind drug-induced toxicity

05:

Identify BK Polyomavirus, Cytomegalovirus, and Epstein-Barr virus

06:

Quantify the relative abundance of 14 different immune cells

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

Functional Annotations
Viral Identification
NHP Compatibility
Product Specifications
Catalog Information
Functional Annotations
Viral Identification

Solid organ and hematopoietic transplant recipients are at increased risk for developing complications from opportunistic viral infections and may even inherit a viral infection from the donor. Knowing if a viral infection is present can be essential to understanding both the immune response and the potential impact of immunosuppressive treatments. Included in the Human Organ Transplant panel are probes specific for the detection of BK Polyomavirus, Cytomegalovirus (CMV) and Epstein-Barr virus (EBV).

NHP Compatibility

Probes included in the Human Organ Transplant Panel have been confirmed to also have high homology to non-human primates providing a valuable tool for translational comparative studies using both human and non-human samples.

Product Specifications
Catalog Information

Related Resources

View All Resources
Product Bulletin Human Organ Transplant Panel – Product Bulletin
Blog Molecular Signatures of Antibody-Mediated Rejection and Graft Outcome After Kidney Transplantation. Q&A with Dr. Dela Golshayan, M.D., Ph.D.
Blog Solid Organ Transplantation and the Immunology of Rejection. Q&A with GeoMx® Digital Spatial Profiler Grant Winner Dr. Fadi Issa
Blog The bench side of organ transplant: Challenges and solutions
Blog Searching for New Biomarkers to Prevent Organ Transplant Rejection. Q&A with HOT Panel Grant Winner Dr. Evan Farkash

The spatial landscape of lung pathology during COVID-19 progression.

Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19)1–8. However, thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking.

Spatial mapping of SARS-CoV-2 and H1N1 Lung Injury Identifies Differential Transcriptional Signatures.

Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear if ARDS from SARS-CoV-2 is similar to that observed in Influenza H1N1, another common viral cause of lung injury.

In-silico performance, validation, and modeling of the Nanostring Banff Human Organ transplant gene panel using archival data from human kidney transplants

RNA gene expression of renal transplantation biopsies is commonly used to identify the immunological patterns of graft rejection. Mostly done with microarrays, seminal findings defined the patterns of gene sets associated with rejection and non-rejection kidney allograft diagnoses.

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