nCounter® Host Response Panel
Helping Your Research
Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics to fight infectious disease. The nCounter® Host Response Panel helps researchers study the phases and progression of infection across the major components of the human or mouse host response with pathogen-agnostic content optimized for blood but suitable for all sample types. The panel was specifically developed for understanding the complexities of the immune response to infectious disease, including COVID-19.
How it Works
The Host Response Panel helps rapidly advance knowledge of emerging infectious disease with experiments that take minutes to set-up and get you results in less than 24 hours.
- Study the five elements of the host response in human or mouse samples
- Host Susceptibility
- Interferon Response
- Innate Immune Cell Activation
- Adaptive Immune Response
- Homeostasis
- Profile 785 genes in human or mouse genes across 50+ pathways
- Detect the presence of a pathogen and evaluate organ-specific tissue damage with a Panel Plus spike-in of up to 55 genes
- Develop signatures of host response dynamics
- Identify and validate biomarkers for disease severity
- Evaluate the effect of vaccines & therapies
Customize your research project by adding tissue or pathogen-specific probes to the Host Response Panel with a 55-gene Panel Plus. Add the off-the-shelf 20-gene Coronavirus Panel Plus to study SARS-CoV-2 and other coronaviruses or build your own Panel Plus gene list with transcripts specific for different tissue types. Mix and match transcripts from the pathogen of your choice and additional host tissue markers to add a Panel Plus to the Host Response Panel for studying the pathogenesis of various infectious diseases. Check out the Human or Mouse Host Response Tissue Gene Lists to see which genes to add as a Panel Plus spike-in to study the effect of infectious disease on different organs.
Add up to 55 viral probes from any specific pathogen or combination of pathogens to the Host Response Panel. The Viral Panel Plus Menu is a list of pre-designed Research Use Only probes for eight viruses associated with chronic disease and/or cancer. Probes were designed to cover as many sequences as possible while at the same time ensuring sensitivity, specificity, and breadth of coverage. Custom probes can be designed to viruses and other pathogens not covered in this list – please contact bioinformatics for more information.
Panel Selection Tool
Find the gene expression panel for your research with easy to use panel pro
Find Your PanelProduct Information
Take advantage of comprehensive coverage of the most relevant immune checkpoints to study modulation of the host immune response and subsequent inflammatory cascade.
Probes included in the Human Host Response Panel have high homology to non-human primates (NHPs), allowing for seamless comparative infectious disease research as well as preclinical studies. Percent identity is used to estimate likelihood of the probe functioning on non-human primate targets. Additional comparisons with other NHP species are available upon request.
Genes included in the Host Response Panel provide unique cell profiling data to measure the relative abundance of 14 different immune cell types. The table below summarizes the genes included in each cell type signature, as qualified through biostatistical approaches and selected literature in the field
Related Resources
Publications
Remodeling of the tumor microenvironment via disrupting Blimp1(+) effector Treg activity augments response to anti-PD-1 blockade.
BACKGROUND: Accumulation of Foxp3(+) regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1.
Gene expression of oxidative stress markers and lung function: A CARDIA lung study.
BACKGROUND: Circulating markers of oxidative stress have been associated with lower lung function. Our objective was to study the association of gene expression levels of oxidative stress pathway genes (ALOX12, ALOX15, ARG2, GSTT1, LPO, MPO, NDUFB3, PLA2G7, and SOD3) and lung function forced expiratory volume in one second (FEV1 ), forced vital capacity (FVC) in Coronary Artery Risk Development in Young Adults study.
Circadian dynamics of the teleost skin immune-microbiome interface.
Background: Circadian rhythms of host immune activity and their microbiomes are likely pivotal to health and disease resistance. The integration of chronotherapeutic approaches to disease mitigation in managed animals, however, is yet to be realised.
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