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nCounter® Autoimmune Profiling Panel

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Helping Your Research

Get insights into immune system dysfunction quickly with our comprehensive 770 gene multiplex panel for human or mouse to evaluate the pathways, processes, and cell types involved in autoimmune disease, chronic inflammatory disease, and immunotherapy-related adverse events. Analyze autoimmune biomarkers rapidly without the need for qPCR or NGS.

  • Therapeutic mechanism of action (MOA) studies
  • Immunotherapy-induced adverse event investigations
  • Discovery/validation of disease and therapeutic specific biomarkers
  • Development of predictive signatures of drug response
  • Compatible with challenging sample types such as PBMCs and FFPE

How it Works

The nCounter Autoimmune Profiling panels are designed to rapidly characterize the biology behind autoimmune disease and an aberrant immune response. Each human and mouse panel allow for a comprehensive evaluation of pathways, processes, and cell types that are involved in autoimmune disease and chronic inflammatory disorders.

01:

Comprehensive assessment of 35 pathways and processes associated with autoimmune disease and chronic inflammatory disorders

02:

Unique cell typing analysis feature measures the relative abundance of 14 different immune cell types

03:

Customizable with Panel Plus option – add up to 55 genes of your choice

04:

Streamlined workflow with just 15 minutes total hands-on time

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

Find Your Panel

The TruCulture-NanoString Solution for Immune Profiling

Recent publications (1,2) from the Milieu Interieur project at Institut Pasteur have shown the utility of the Myriad RBM TruCulture(1) whole blood collection and culture system paired with nCounter gene expression analysis.

For more information on the combined TruCulture-NanoString workflow, visit the Myriad TruCulture site.


In the Lab

Investigating the Immune
Response with theTruCulture® System and the nCounter® Autoimmune Profiling Panel

Read More
True Culture Note

Product Information

Autoimmune Profiling Pathways and Processes
Immune Cell Profiling
Autoimmune Disease and Chronic Inflammatory Disease Coverage
Targets for Approved and Investigational Therapies
Product Specifications
Autoimmune Profiling Pathways and Processes

The 35 pathways and processes in this panel provide a comprehensive view into immune system dysfunction in autoimmune disease and treatment-induced adverse immune events.

Immune Cell Profiling

The Autoimmune Profiling Panels include unique cell profiling signatures to measure the relative abundance of 14 different immune cell types1. The table below summarizes each cell type represented by gene content in the panel, as qualified through biostatistical approaches and selected literature in the field of immunology.

Autoimmune Disease and Chronic Inflammatory Disease Coverage

The Autoimmune Profiling Panel is designed to encompass adaptive and innate immune system dysfunction associated with six of the most common and debilitating autoimmune diseases. The table below describes the six conditions that were emphasized in creating this panel, along with induced adverse immune events associated with immunotherapy. While this panel was designed around these six diseases, it will provide powerful immune system information for the research of any autoimmune or chronic inflammatory disorder.

Targets for Approved and Investigational Therapies

Content in the Autoimmune Profiling Panel includes targets for more than 30 approved and investigational therapies for autoimmune disease and chronic inflammatory disorders.

Product Specifications

Related Resources

View All Resources
Product Bulletin Autoimmune Profiling Panel – Product Bulletin
Flyer Autoimmune Publications – Flyer
Blog How to Resolve the Complexity of Autoimmune Diseases
Webinar Take on the challenges of Autoimmunity research with the nCounter® Analysis System
Webinar Investigating the Human Immune Response with Myriad RBM’s TruCulture® System & NanoString® nCounter® Autoimmune Profiling Panel

Publications

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Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea.

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to have kidney-protective benefits. To elucidate how antidiabetic agents prevent diabetic kidney disease progression, it is important to investigate their effect on the kidney environment in type 2 diabetes mellitus (DM) patients.

Monogenic Autoinflammatory Diseases: State of the Art and Future Perspectives.

Systemic autoinflammatory diseases are a heterogeneous family of disorders characterized by a dysregulation of the innate immune system, in which sterile inflammation primarily develops through antigen-independent hyperactivation of immune pathways. In most cases, they have a strong genetic background, with mutations in single genes involved in inflammation.

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.

The prevalence of autoimmune diseases is on the rise globally. Currently, autoimmunity presents in over 100 different forms and affects around 9% of the world’s population.

Skysphere

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