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nCounter® Autoimmune Discovery Panel

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Helping Your Research

The nCounter Autoimmune Discovery Panel is designed to enable researchers to discover links between known autoimmune disease associated germline variants and gene expression. The genes were selected in collaboration with leading autoimmune researchers and are linked to the top nine autoimmune diseases. This panel is made-to-order and you can add on up to 55 gene targets to the panel with the Panel Plus product to customize the panel to your research project.

How it Works

The Human nCounter Autoimmune Discovery Panel is a 770-gene panel that provides analysis of the links between known disease associated mutations and gene expression changes, allowing researchers to identify new gene functions and to look at gene expression in response to treatment. Highlights of the Autoimmune Discovery Panel include:

01:

Discovery tool for disease-associated mutation gene function studies and biomarker characterization

02:

Comprehensive content associated with nine autoimmune diseases

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Gene expression profiling of immune response together with gene mutations

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Made-to-order & customizable with the Panel Plus option – add up to 55 user-defined genes

05:

Simple workflow, user-friendly, and efficient with just 15 minutes total hands-on time

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

Specifications
Panel Content
Specifications
Panel Content

Coverage of Autoimmune Diseases

Disease-specific annotations for nine autoimmune disease types and human immune response genes were assigned across all genes in the autoimmune discovery panel, allowing for the identification of gene functions and signatures for all autoimmune diseases.

Related Resources

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Product Bulletin Autoimmune Discovery Panel – Product Bulletin
Flyer Autoimmune Publications – Flyer
Webinar Defining the function of genes associated with chronic inflammatory diseases: The nCounter® Autoimmune Discovery Consortium Panel
Webinar Take on the challenges of Autoimmunity research with the nCounter® Analysis System
Blog Characterizing Severe Autoimmune Toxicities Associated with Checkpoint Inhibitor Therapies

Publications

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Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea.

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to have kidney-protective benefits. To elucidate how antidiabetic agents prevent diabetic kidney disease progression, it is important to investigate their effect on the kidney environment in type 2 diabetes mellitus (DM) patients.

Monogenic Autoinflammatory Diseases: State of the Art and Future Perspectives.

Systemic autoinflammatory diseases are a heterogeneous family of disorders characterized by a dysregulation of the innate immune system, in which sterile inflammation primarily develops through antigen-independent hyperactivation of immune pathways. In most cases, they have a strong genetic background, with mutations in single genes involved in inflammation.

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.

The prevalence of autoimmune diseases is on the rise globally. Currently, autoimmunity presents in over 100 different forms and affects around 9% of the world’s population.

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