Autoimmune Discovery Panel
Helping Your Research
The nCounter Autoimmune Discovery Panel is designed to enable researchers to discover links between known autoimmune disease associated germline variants and gene expression. The genes were selected in collaboration with leading autoimmune researchers and are linked to the top nine autoimmune diseases. This panel is made-to-order and you can add on up to 55 gene targets to the panel with the Panel Plus product to customize the panel to your research project.
How it Works
The Human nCounter Autoimmune Discovery Panel is a 770-gene panel that provides analysis of the links between known disease associated mutations and gene expression changes, allowing researchers to identify new gene functions and to look at gene expression in response to treatment. Highlights of the Autoimmune Discovery Panel include:
Discovery tool for disease-associated mutation gene function studies and biomarker characterization
Comprehensive content associated with nine autoimmune diseases
Gene expression profiling of immune response together with gene mutations
Made-to-order & customizable with the Panel Plus option – add up to 55 user-defined genes
Simple workflow, user-friendly, and efficient with just 15 minutes total hands-on time
Panel Selection Tool
Find the gene expression panel for your research with easy to use panel proFind Your Panel
Coverage of Autoimmune Diseases
Disease-specific annotations for nine autoimmune disease types and human immune response genes were assigned across all genes in the autoimmune discovery panel, allowing for the identification of gene functions and signatures for all autoimmune diseases.
Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells.
AIMS/HYPOTHESIS: Diabetes mellitus causes a progressive loss of functional efficacy in stem cells, including cardiac progenitor cells (CPCs). The underlying molecular mechanism is still not known.
Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice.
Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases. cSiO2’s autoimmune effects in humans can be mimicked chronically in female lupus-prone NZBWF1 mice following repeated exposure to the particle.
A Novel Inflammatory Dendritic Cell That Is Abundant and Contiguous to T Cells in the Kidneys of Patients With Lupus Nephritis.
The mechanisms that promote local inflammatory injury during lupus nephritis (LN) flare are largely unknown. Understanding the key immune cells that drive intrarenal inflammation will advance our knowledge of disease pathogenesis and inform the development of new therapeutics for LN management.