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nCounter®
Autoimmune Discovery Panel

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Helping Your Research

The nCounter Autoimmune Discovery Panel is designed to enable researchers to discover links between known autoimmune disease associated germline variants and gene expression. The genes were selected in collaboration with leading autoimmune researchers and are linked to the top nine autoimmune diseases. This panel is made-to-order and you can add on up to 55 gene targets to the panel with the Panel Plus product to customize the panel to your research project.

How it Works

The Human nCounter Autoimmune Discovery Panel is a 770-gene panel that provides analysis of the links between known disease associated mutations and gene expression changes, allowing researchers to identify new gene functions and to look at gene expression in response to treatment. Highlights of the Autoimmune Discovery Panel include:

01:

Discovery tool for disease-associated mutation gene function studies and biomarker characterization

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Comprehensive content associated with nine autoimmune diseases

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Gene expression profiling of immune response together with gene mutations

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Made-to-order & customizable with the Panel Plus option – add up to 55 user-defined genes

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Simple workflow, user-friendly, and efficient with just 15 minutes total hands-on time

Panel Selection Tool

Find the gene expression panel for your research with easy to use panel pro

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Product Information

Specifications
Panel Content
Specifications
Panel Content

Coverage of Autoimmune Diseases

Disease-specific annotations for nine autoimmune disease types and human immune response genes were assigned across all genes in the autoimmune discovery panel, allowing for the identification of gene functions and signatures for all autoimmune diseases.

Related Resources

See All Resources
Product Bulletin Autoimmune Discovery Panel – Product Bulletin
Flyer Autoimmune Publications – Flyer
Webinar Defining the function of genes associated with chronic inflammatory diseases: The nCounter® Autoimmune Discovery Consortium Panel
Blog The Chronic(als) of Autoimmunity
Webinar Take on the challenges of Autoimmunity research with the nCounter® Analysis System

Publications

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Gastric Mucosal Immune Profiling and Dysregulation in Idiopathic Gastroparesis.

It is unclear how immune perturbations may influence the pathogenesis of idiopathic gastroparesis, a prevalent functional disorder of the stomach which lacks animal models. Several studies have noted altered immune characteristics in the deep gastric muscle layer associated with gastroparesis, but data are lacking for the mucosal layer, which is endoscopically accessible.

Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity.

A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent years. This so-called gut–CNS axis can be shaped by dietary factors, either directly or via indirect modulation of the gut microbiome and its metabolites.

Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion.

Tim-3 adaptor protein Bat3 regulates T cell terminal differentiation and exhaustion in an mTORC2-dependent manner.

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