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GeoMx® Immune Pathways Panel

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Targeted Content for Cancer Biology

The GeoMx Immune Pathways Panel is designed for targeted profiling of the tumor, tumor microenvironment, and tumor immune status.

Profile up to 96 RNA targets with spatial resolution from a single tissue section using the GeoMx Digital Spatial Profiler (DSP).

How it Works

About
GeoMx® Immune Pathways Panel
About

The Immune Pathways panel contains 84 targets plus controls designed for broad coverage of the tumor and tumor microenvironment. GeoMx RNA assays contain in situ hybridization (ISH) probes conjugated to unique DNA indexing-oligonucleotides via a UV-photocleavable linker. After region of interest (ROI) selection on GeoMx DSP and UV cleavage of the oligonucleotides, each DNA oligonucleotide is recognized by a unique Reporter probe that contains a fluorescent barcode. Reporter probes are imaged and counted by the nCounter® Analysis System to provide a direct, digital readout of spatially resolved RNA expression.

  • Curated content designed for immuno-oncology research
  • Includes tumor and tumor microenvironment coverage plus the Tumor Inflammation Signature (TIS)
  • Pre-validated in multiplex format for use in human FFPE or fresh frozen tissue
  • Compatible with RNAscope® and antibody morphology markers for tissue imaging
  • Customizable with up to 10 additional targets of interest
  • For use with nCounter readout and compatible with DSP Data Center
GeoMx® Immune Pathways Panel

Curated Content for Immuno-Oncology

The GeoMx Immune Pathways panel is designed to profile key aspects of the tumor and tumor microenvironment biology.

  • Profile the global immune response
  • Assess microenvironment immune activity
  • Quantify tumor reactivity
  • Measure the 18-gene Tumor Inflammation Signature known to be associated with response to PD-1/PD-L1 inhibitor pathway blockade

Accompanying Morphology Marker Kits are available for tissue visualization and ROI selection.

Publications

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From bulk, single-cell to spatial RNA sequencing.

RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq).

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb.

Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure.

Novel intragraft regulatory lymphoid structures in kidney allograft tolerance.

Intragraft events thought to be relevant to the development of tolerance are here subjected to a comprehensive mechanistic study during long term spontaneous tolerance that occurs in C57BL/6 mice that receive life sustaining DBA/2 kidneys. These allografts rapidly develop periarterial Treg-rich organized lymphoid structures (TOLS) that form in response to class II but not to class I MHC disparity and form independently of lymphotoxin α and lymphotoxin β receptor pathways.

Related Resources

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Brochure/eBook GeoMx DSP – Brochure
Report DSP TAP Sample Report
Skysphere

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