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Geometric profiling

Assess tissue heterogeneity profiling standardized geometric shapes across distinct tissue regions

What is the expression of neural cell type specific and neuropathology related proteins in distinct brain regions?

Geometric profiling identifies distinct expression profiles across and within specific regions of the tissue

How does the expression of tumor and immune markers differ across a sample?

Geometric profiling identifies distinct expression profiles across and within specific regions of the tissue

Segment profiling

Maximize cellularity using morphology markers to identify and profile distinct biological compartments within a ROI

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How does the tumor differ from the tumor microenvironment?

Segment profiling reveals unique tumor and tumor microenvironment molecular profiles

Contour profiling

Evaluate the how proximity affects biological response and the local microenvironment around a central structure using radiating ROIs

What is the expression profile of the plaque microenvironment?

Radiating circles surrounding amyloid beta plaques show distinct expression profiles

How does proximity to the tumor or an immune cell population alter biological response?

Radiating ROIs surrounding macrophages show distinct expression profiles based on proximity

Gridded profiling

Perform deep spatial mapping using a tunable gridding pattern

What novel biology is uncovered with deep spatial mapping of the brain?

Gridded profiling provides a digital map of the molecular profile of the brain

What novel biology is uncovered with deep spatial mapping of the tumor?

Gridded profiling provides a digital map of the molecular profile of the tumor

Rare cell profiling

Reveal the function of distinct cell populations with cell type specific morphology markers guiding ROI selection

How do specific cellular subpopulations impact neurobiology and disease progression?

Isolated microglial populations show unique expression profiles

How do rare immune cells impact tumor biology and therapeutic response?

Isolated immune cell populations show unique expression profiles