GeoMx® Digital Spatial Profiler
Discover Where Biology Happens
Helping Your Research
Understanding tissue heterogeneity is critical to answering key biological questions. The current tissue analysis paradigm requires a tradeoff between low-plex spatial analysis or high-plex bulk analysis, sacrificing valuable information and consuming precious samples. NanoString’s GeoMx Digital Spatial Profiler (DSP) combines the best of spatial and molecular profiling technologies by generating digital whole transcriptomes and profiling data for 100s of validated Protein analytes from up to 12 tissue slides per day. This unique combination of high-plex and high-throughput spatial profiling enables researchers to rapidly and quantitatively assess the biological implications of the heterogeneity within tissue samples. From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial solution designed to conform to your ever-changing research needs.
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How it Works
The GeoMx DSP workflow seamlessly integrates with current histology methods to get you robust and reproducible spatial omics data quickly. Stain for RNA or Protein from FFPE or fresh frozen tissue sections, precisely select which tissue compartments or cell types you want to profile based on the biology, and readout expression levels using either the nCounter Analysis System or an Illumina sequencer.
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GeoMx Publications
From bulk, single-cell to spatial RNA sequencing.
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq).
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb.
Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure.
Novel intragraft regulatory lymphoid structures in kidney allograft tolerance.
Intragraft events thought to be relevant to the development of tolerance are here subjected to a comprehensive mechanistic study during long term spontaneous tolerance that occurs in C57BL/6 mice that receive life sustaining DBA/2 kidneys. These allografts rapidly develop periarterial Treg-rich organized lymphoid structures (TOLS) that form in response to class II but not to class I MHC disparity and form independently of lymphotoxin α and lymphotoxin β receptor pathways.
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