GeoMx® Digital Spatial Profiler
The Spatial Biology Solution
Helping Your Research
Understanding tissue heterogeneity is critical to answering key biological questions. The current tissue analysis paradigm requires a tradeoff between low-plex spatial analysis or high-plex bulk analysis, sacrificing valuable information and consuming precious samples. NanoString’s GeoMx Digital Spatial Profiler (DSP) combines the best of spatial and molecular profiling technologies by generating digital whole transcriptomes and profiling data for 100’s of validated Protein analytes from up to 12 tissue slides per day. This unique combination of high-plex and high-throughput spatial profiling enables researchers to rapidly and quantitatively assess the biological implications of the heterogeneity within tissue samples. From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial solution designed to conform to your ever-changing research needs.
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Experience automated or customized region of interest (ROI) selection based on the biology of the sample. From tumor and microenvironment down to the single cell resolution, flexible selection allows you to get to answers faster.
Expand your research scope with access to more sample types. From the most challenging sample types, including Formalin-Fixed Paraffin-Embedded and Fresh Frozen tissue, your research is not limited by type of sample leading to broader discovery and robust data.
How it Works
The GeoMx DSP data center provides an end-to-end software solution from image acquisition, region of interest selection to a fully integrated data analysis experience.
in Your Lab
Spatially resolved transcriptomics and its applications in cancer
Spatially resolved transcriptomics (SRT) offers the promise of understanding cells and their modes of dysfunction in the context of intact tissues. Technologies for SRT have advanced rapidly with a large number being published in recent years.
Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors
In recent years, cancer immunotherapy experienced remarkable developments and it is nowadays considered a promising therapeutic frontier against many types of cancer, especially hematological malignancies. However, in most types of solid tumors, immunotherapy efficacy is modest, partly because of the limited accessibility of lymphocytes to the tumor core.
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18-SSX fusion, and is characterized by low T cell infiltration. Here, we studied the cancer-immune interplay in SyS using an integrative approach that combines single-cell RNA sequencing (scRNA-seq), spatial profiling and genetic and pharmacological perturbations.