GeoMx® Digital Spatial Profiler
The Spatial Biology Solution
Helping Your Research
Understanding tissue heterogeneity is critical to answering key biological questions. The current tissue analysis paradigm requires a tradeoff between low-plex spatial analysis or high-plex bulk analysis, sacrificing valuable information and consuming precious samples. NanoString’s GeoMx Digital Spatial Profiler (DSP) combines the best of spatial and molecular profiling technologies by generating digital whole transcriptomes and profiling data for 100s of validated Protein analytes from up to 12 tissue slides per day. This unique combination of high-plex and high-throughput spatial profiling enables researchers to rapidly and quantitatively assess the biological implications of the heterogeneity within tissue samples. From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial solution designed to conform to your ever-changing research needs.
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How it Works
The GeoMx DSP workflow seamlessly integrates with current histology methods to get you robust and reproducible spatial omics data quickly. Stain for RNA or Protein from FFPE or fresh frozen tissue sections, precisely select which tissue compartments or cell types you want to profile based on the biology, and readout expression levels using either the nCounter Analysis System or an Illumina sequencer.
in Your Lab
Models that combine transcriptomic with spatial protein information exceed the predictive value for either single modality.
Immunotherapy has reshaped the field of cancer therapeutics but the population that benefits are small in many tumor types, warranting a companion diagnostic test. While immunohistochemistry (IHC) for programmed death-ligand 1 (PD-L1) or mismatch repair (MMR) and polymerase chain reaction (PCR) for microsatellite instability (MSI) are the only approved companion diagnostics others are under consideration.
Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies.
Cutaneous melanoma is an aggressive tumor responsible for 90% of mortality related to skin cancer. In the recent years, the discovery of driving mutations in melanoma has led to better treatment approaches.
Multiplexed digital spatial profiling of invasive breast tumors from Black and White women.
The NanoString GeoMx Digital Spatial Profiling (DSP) is a new multiplexed platform that quantifies the abundance of tumor- and immune-related proteins in a spatially resolved manner. We performed DSP for the simultaneous assessment of 52 analytes within spatially resolved tissue compartments defined by pan-cytokeratin expression.