GeoMx® Digital Spatial Profiler
The Spatial Biology Solution
Helping Your Research
Understanding tissue heterogeneity is critical to answering key biological questions. The current tissue analysis paradigm requires a tradeoff between low-plex spatial analysis or high-plex bulk analysis, sacrificing valuable information and consuming precious samples. NanoString’s GeoMx Digital Spatial Profiler (DSP) combines the best of spatial and molecular profiling technologies by generating digital whole transcriptomes and profiling data for 100s of validated Protein analytes from up to 12 tissue slides per day. This unique combination of high-plex and high-throughput spatial profiling enables researchers to rapidly and quantitatively assess the biological implications of the heterogeneity within tissue samples. From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial solution designed to conform to your ever-changing research needs.
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How it Works
The GeoMx DSP data center provides an end-to-end software solution from image acquisition, region of interest selection to a fully integrated data analysis experience.
in Your Lab
The spatial landscape of lung pathology during COVID-19 progression.
Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19)1–8. However, thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking.
GeoMx RNA Assay: High Multiplex, Digital, Spatial Analysis of RNA in FFPE Tissue.
RNA in situ hybridization (ISH) is a widely used technique for the localization of mRNA in tissues. Limitations to traditional ISH include the number of targets that can be analyzed concurrently and the ability for many of these assays to be used in formalin-fixed, paraffin-embedded tissues (FFPE).
Spatial mapping of SARS-CoV-2 and H1N1 Lung Injury Identifies Differential Transcriptional Signatures.
Severe SARS-CoV-2 infection often leads to development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear if ARDS from SARS-CoV-2 is similar to that observed in Influenza H1N1, another common viral cause of lung injury.