nCounter® Autoimmune Discovery 
Panel on Demand

This human 770-gene multiplex panel-on-demand provides analysis of the links between known disease associated mutations and gene expression, allowing researchers to identify new gene functions and to look at gene expression in response to treatment. 

  • Autoimmune panel that covers rheumatoid arthritis, multiple sclerosis, Ankylosing spondylitis, chrohn's disease, irritable bowel disease, ulcerative colitis, Antiphospholipid syndrome, type 1 diabetes, and systemic lupus erythematosusDiscovery tool for disease-associated mutation gene function and biomarker characterization
  • Comprehensive content with variants across nine of the top autoimmune diseases
  • Gene expression profiling of immune response together with gene mutations
  • Customizable with panel-plus option – add up to 30 user-defined genes
  • Workflow is simple, user-friendly, and efficient with just 15 minutes total hands-on time

Disease specific annotations for nine autoimmune disease types and human immune response genes were assigned across all genes in the autoimmune discovery panel allowing for the identification of gene functions and signatures for all autoimmune diseases.

Disease Type Association Description Genes
Multiple Sclerosis Demyelinating disease of the nervous system 104
Rheumatoid Arthritis Chronic inflammatory disorder of joints 95
Systemic Lupus Erythematosus Inflammation and damage to various body tissues 55
Type 1 Diabetes Disease that causes damage to beta cells in the pancreas 44
Ankylosing Spondylitis Chronic inflammatory disorder of the spine 43
Celiac Disease Immune response to gluten that damages small intestine 249
Ulcerative Colitis Disease causing inflammation and ulcers in large intestine 200
Inflammatory Bowel Disease Inflammation of the digestive tract 249
Psoriasis Deficiency in function of multiple endocrine glands 48
Other Immune Response Human immune response genes 237

 

Feature Specifications
Number of Targets 770 (Human) including internal reference genes
Standard Input Material (No amplification required) 25 ng-300 ng
Sample Type(s) FFPE-derived RNA, total RNA, fragmented RNA, cell lysates, PBMCs, whole blood/plasma, urine, saliva, cerebral spinal fluid, synovial fluid
Customizable Add up to 30 unique genes with Panel-Plus
Time to Results Approximately 24 hours
Data Analysis nSolver Analysis Software

 

Panel on Demand

The Autoimmune Discovery Panel is now available as a Panel on Demand.  Using the identical or modified gene list NanoString can create a panel for your individual needs.  Please contact your local sales representative or send your request to us at panels@nanostring.com.

 

For Research Use Only. Not for use in diagnostic procedures.