Hallmarks of Cancer Panel Collection

The Hallmarks of Cancer are one of the most widely recognized organizing principles for the holistic study of cancer. Its profoundly simple framework was first introduced in 2000 by authors Douglas Hanahan and Robert Weinberg and defines a distinct set of acquired capabilities that distinguish cancer from normal tissue. This framework, represented in the now-famous Hallmarks of Cancer wheel (shown below), is often the first roadmap researchers use to study all types of cancer and is the foundation of our PanCancer panels.

The Hallmarks of Cancer Panel collection delivers a family of multiplex gene expression assays to enable basic and translational research into pathway deregulation studies, immune profiling, and cancer progression.

  • NanoString’s PanCancer panels provide a comprehensive coverage of all ten Hallmarks of Cancer
  • >1,850 unique genes included across all panels
  • Advanced data analysis modules for pathway deregulation and immune cell profiling
  • Customize panels with up to 30 additional user-defined genes
  • Compatible with protein panels for multi-omics assays

Reference: The Hallmarks of Cancer. Originally published in Cell, 144, Hanahan D & Weinberg RA, Hallmarks of Cancer: The Next Generation, 646-674, © Elsevier, 2011.


Simple workflow produces data in less than 24 hours

nCounter® Gene Expression panels are the quickest way to obtain high-quality data from your samples on the nCounter® system. Compatible with a range of different sample types and with 15 minutes of total hands-on time, getting answers from your nCounter® panel experiment is both convenient and easy.

Gene Expression Panel Code Sets

  • Panel CodeSets arrive ready-to-use and generally ship within 24 hours following your purchase.
  • No library prep or dilutions required.
  • Requires as little as 25 ng total RNA input material.
  • Primer pools or primer designs available for use with multi-target enrichment for low input material or single-cell analysis.

Examples of compatible Sample Types

  • FFPE-derived RNA, Total RNA, Fragmented RNA
  • Cell lysates
  • PBMCs
  • Whole blood/Plasma/Serum
  • Urine
  • Saliva
  • Cerebral spinal fluid
  • Synovial fluid

Fully-annotated gene lists in Excel format are available online for each of the PanCancer panels. All gene lists include the official gene name, accession number, alias, target sequence, and sortable annotations. The table below lists some of the major gene categories or pathways along with the panel in which they are best represented.

Category/Pathway

Number of Genes

Panel Name

Representative Hallmarks

Adaptive immunity

104

PanCancer Immune Profiling

Avoiding immune destruction

Angiogenesis

277

PanCancer Progression

Inducing angiogenesis

Cancer driver genes

124

PanCancer Pathways

Cell cycle and apoptosis

137

PanCancer Pathways

Resisting cell death

Chromatin modification

22

PanCancer Pathways

Genome instability and mutation

DNA repair

50

PanCancer Pathways

Genome instability and mutation

Epithelial-mesenchymal transition

269

PanCancer Progression

Activating invasion and metastasis

Extracellular matrix

254

PanCancer Progression

Activating invasion and metastasis

Hedgehog pathway

28

PanCancer Pathways

Resisting cell death

Humoral immunity

41

PanCancer Immune Profiling

Avoiding immune destruction

Inflammation

66

PanCancer Immune Profiling

Tumor-promoting inflammation

Innate immunity

200

PanCancer Immune Profiling

Tumor-promoting inflammation

JAK-STAT pathway

86

PanCancer Pathways

Sustaining proliferative signaling

MAPK pathway

157

PanCancer Pathways

Sustaining proliferative signaling

Metastasis

173

PanCancer Progression

Activating invasion and metastasis

Notch pathway

24

PanCancer Pathways

Enabling replicative immortality

PI3K pathway

201

PanCancer Pathways

Deregulating cellular energetics

RAS pathway

142

PanCancer Pathways

Sustaining proliferative signaling

TGF- pathway

51

PanCancer Pathways

Evading growth suppressors

Transcriptional misregulation

101

PanCancer Pathways

Genome instability and mutation

Wnt pathway

78

PanCancer Pathways

Enabling replicative immortality

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For Research Use Only. Not for use in diagnostic procedures.