Reproducibly translate mouse models of Alzheimer’s disease (AD) to human disease with 770 standardized genes covering 30 clinically derived AD-associated modules discovered in the AMP-AD consortium study of human brain tissue. Reliably assay AD phenotypes and disease progression for mouse model development and human tissue screening. Perform in vivo screening of potential therapeutics with an efficient and translational workflow to potentially reduce time to the clinic.
- Monitor disease progression with age
- Assay novel therapeutics
- Characterize AD
- Customizable with up to 30 additional user-defined genes with Panel Plus option
nSolver Advanced Analysis Modules available for Mouse AD and Human AD include:
- Pathway Based Module Analysis
- Pathway Analysis
- Quality Control
- Differential Expression
- Gene Set Analysis
- Built-in compatibility for Panel Plus and Protein analysis
New Insights into Neuroscience Research
Explore this publication review of top neuroscience studies to see how gene expression technology is reshaping research capabilities in neuroscience.
AMP-AD consortium study
Read "Heterogeneity across human AD coexpression modules identified by meta-analysis of the human brain transcriptome”
|Module||Enriched Pathways and Processes Represented†||Mouse/Human Genes*|
|CBEblue||Transcription and Splicing||176|
|CBEbrown||Lipid Metabolism, Myelination||95|
|CBEyellow||Vesicle Trafficking, Transmitter Synthesis and Storage||156/157|
|DLPFCbrown||Lipid Metabolism, Myelination||139|
|DLPFCturquoise||Transcription and Splicing||143|
|DLPFCyellow||Transmitter Synthesis and Storage, Vesicle Trafficking, Transmitter Release, Neural Connectivity||191/193|
|FPblue||Lipid Metabolism, Myelination||277|
|FPyellow||Vesicle Trafficking, Transmitter Synthesis and Storage, Neural Connectivity, Transmitter Release||187/188|
|IFGblue||Transcription and Splicing, Lipid Metabolism, Myelination||236|
|IFGbrown||Transmitter Synthesis and Storage, Vesicle Trafficking, Transmitter Release, Neural Connectivity||232/235|
|PHGblue||Transcription and Splicing||170|
|PHGbrown||Transmitter Synthesis and Storage, Vesicle Trafficking||164/165|
|PHGgreen||Lipid Metabolism, Myelination||139|
|STGbrown||Transmitter Synthesis and Storage, Vesicle Trafficking, Neural Connectivity, Transmitter Release, Transmitter Response and Reuptake||210/212|
|STGturquoise||Transcription and Splicing||118|
|STGyellow||Lipid Metabolism, Myelination||159|
|TCXbrown||Transcription and Splicing||124|
|TCXgreen||Transmitter Synthesis and Storage, Vesicle Trafficking||185/187|
|Internal Reference Genes||‡||10|
† Annotations for 23 fundamental pathways and processes were assigned across all genes in the Mouse AD and Human AD panel allowing for an additional view of important aspects of the onset and progression of neurodegenerative disease. Pathways and processes with >60% representative gene content per module are listed above. Additional annotations can be found in the complete gene list.
‡ <60% representative pathway and process gene content per module
* Genes selected based on human-mouse gene homology, maximal coverage of AMP-AD modules, top AGORA candidate gene status (agora.ampadportal.org), representation in AMP-AD module eigengenes, and expression in mouse brain.
|Number of Targets||770 including internal reference genes|
|Standard Input Material (No amplification required)||25 ng-300 ng|
|Sample Type(s)||FFPE-derived RNA, total RNA, fragmented RNA, PBMCs, whole blood/plasma, iPS cells|
|Species||Mouse and Human|
|Customizable||Add up to 30 unique genes with Panel-Plus|
|Time to Results||Approximately 24 hours|
|Data Analysis||nSolver™ Analysis Software, Advanced Analysis Modules|
Selected Panel References:
1. ROSMAP: Bennett DA, et al. Overview and Findings from the Religious Orders Study. Current Alzheimer Research. 2012; 9(6): 628-45.
2. Mayo: Allen M et al. Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases. Scientific Data. 2016; 3.
3. MSBB: Wang M et al. The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer’s disease. Scientific Data. 2018; 5.
4. Logsdon BA, Perumal T, et al. Heterogeneity across human AD coexpression modules identified by meta-analysis of the human brain transcriptome. bioRxiv. 2019; 510420.
5. AMP-AD Knowledge Portal (www.ampadportal.org)
6. Carter et al. Translational Genetic and Genomic Analyses of New Mouse Models of Alzheimer’s Disease. Neuroscience 2018.
nCounter Neuroscience Publications
Click here to view nCounter Neuroscience Publications.
|Product||Product Description||Quantity||Catalogue Number|
|nCounter® Mouse AD Panel||Includes 770 genes, including 10 internal reference genes for data normalization||12 reactions||XT-CSO-MAD1-12|
|nCounter® Human AD Panel||Includes 770 genes, including 10 internal reference genes for data normalization||12 reactions||XT-CSO-HAD1-12|
For Research Use Only. Not for use in diagnostic procedures.