NanoString’s PanCancer Panels provide comprehensive coverage of all ten Hallmarks of Cancer1. This collection is a triad of multiplex gene expression assays enabling basic and translational research into pathway deregulation studies, immune profiling, and cancer progression.
- > 1,850 unique genes included across all panels
- Advanced data analysis modules for pathway deregulation and immune cell profiling
- Customize panels with up to 30 additional user-defined genes
- Compatible with protein panels for multi-omics assays
1Reference: The Hallmarks of Cancer. Originally published in Cell, 144, Hanahan D & Weinberg RA, Hallmarks of Cancer: The Next Generation, 646-674, © Elsevier, 2011
The Hallmarks of Cancer are one of the most widely recognized roadmaps for the holistic study of cancer. Its profoundly simple framework was first introduced in 2000 by authors Douglas Hanahan and Robert Weinberg and defines a distinct set of acquired capabilities that distinguish cancer from normal tissue. This framework, represented in the now-famous Hallmarks of Cancer wheel (shown above), is often the first visual guide researchers use to study all types of cancer and is the foundation of our PanCancer Panels.
Fully-annotated gene lists in Excel format are available for each of the PanCancer panels. All gene lists include the official gene name, accession number, alias, target sequence, and sortable annotations. The table below lists some of the major gene categories or pathways along with the panel in which they are best represented.
|Panel||Pathway/Category||Number of Genes||Representative Hallmarks|
|PanCancer Immune Profiling||Adaptive immunity||104||Avoiding immune destruction|
|Humoral immunity||41||Avoiding immune destruction|
|Innate immunity||200||Tumor-promoting inflammation|
|PanCancer Pathways||Cancer driver genes||124||—|
|Cell cycle and apoptosis||137||Resisting cell death|
|Chromatin modification||22||Genome instability and mutation|
|DNA repair||50||Genome instability and mutation|
|Hedgehog pathway||28||Resisting cell death|
|JAK-STAT pathway||86||Sustaining proliferative signaling|
|MAPK pathway||157||Sustaining proliferative signaling|
|Notch pathway||24||Enabling replicative immortality|
|PI3K pathway||201||Deregulating cellular energetics|
|RAS pathway||142||Sustaining proliferative signaling|
|TGF- pathway||51||Evading growth suppressors|
|Transcriptional misregulation||101||Genome instability and mutation|
|Wnt pathway||78||Enabling replicative immortality|
|PanCancer Progression||Angiogenesis||277||Inducing angiogenesis|
|Epithelial-mesenchymal transition||269||Activating invasion and metastasis|
|Extracellular matrix||254||Activating invasion and metastasis|
|Metastasis||173||Activating invasion and metastasis|
For Research Use Only. Not for use in diagnostic procedures.