360 Series Panel Collection

MK2570_Immune-response-graphic_r3-01.png

Inspired by systems biology approaches to cancer research, NanoString's 360 Series Panel Collection gives you a 360° view of gene expression by combining carefully-curated content involved in the biology of the tumor, microenvironment, and the immune response into a single holistic assay. Each panel contains the 18-gene Tumor Inflammation Signature (TIS) that measures a peripherally-suppressed, adaptive immune response and has been shown to correlate with response to checkpoint inhibitors.

Ideal for studying solid tumors, the 360 Series Panel Collection can be used to better understand the biology behind therapeutic response, therapeutic mechanism of action, immune evasion, and the interplay between the tumor and microenvironment. These panels serve as powerful tools for developing novel signatures that correlate with response and/or survival.

  • 1,588 unique genes included across all panels
  • PAM50, Claudin-Low, & Triple Negative Breast Cancer (TNBC) gene signatures included in the Breast Cancer 360 Panel
  • Data Analysis Service for the IO 360 and Breast Cancer 360 Panels provides interactive and customizable reports with signatures scores
  • Pairs with GeoMx® Cancer Transcriptome Atlas for comparative spatial RNA profiling

 

Fully-annotated gene lists in Excel format are available for each of the 360 Panels. The table below compares the biology coverage of the 360 Panels across the tumor, microenvironment, and the immune response to that of the PanCancer Panels Collection.

Panel Name Tumor Microenvironment Immune Response Tumor Inflammation Signature Included PAM50 Signature Included 360 Data Analysis Report Included
Biology Coverage
Pan Cancer Panel Collection
PanCancer Immune Profiling 10% 0% 90% No No No
PanCancer Pathways 100% 0% 0% No No No
PanCancer Progression 30% 70% 0% No No No
360 Series Panel Collection
IO 360 20% 20% 60% Yes No Yes
BC 360 60% 20% 20% Yes Yes Yes
Tumor Signaling 360 70% 15% 15% Yes No No*
*Although the full IO360 report is not available, a standalone TIS report can be purchased.

The Tumor Inflammation Signature1 includes 18 functional genes often associated with the response to PD-1/PD-L1 checkpoint inhibitors. It is embedded into all of the 360 series panels: The PanCancer IO 360 Panel, the Breast Cancer 360 Panel, and the Tumor Signaling 360 Panel.

tumor-inflammation-signature.png

  • Includes four areas of immune biology: IFN-ү-responsive genes related to antigen presentation, chemokine expression, cytotoxic activity, and adaptive immune resistance genes.
  • Highlights the complex biology of the host immune microenvironment.
18-Gene Tumor Inflammation Signature
CCL5 CD8A STAT1 PD-L2/PDCD1LG2 HLA-DQA1 HLA-DRB1
CXCL9 CXCR6 TIGIT PD-L1/CD274 HLA-E CMKLR1
CD27 IDO1 LAG3 CD276 PSMB10 NKG7

View publication and video.

1. Ayers, Mark, et al. "IFN-y-related mRNA profile predicts clinical response to PD-1 blockade." The Journal of Clinical Investigation 127.8 (2017).

For Research Use Only. Not for use in diagnostic procedures.