Designed to identify the most meaningful variants across a variety of solid tumor types, this panel includes somatic variants (SNVs, DNVs, and small InDels) associated with lung adenocarcinoma, thyroid carcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and melanoma. The genes and mutations covered are relevant to new and existing clinical trials, drug pipelines, tumor subtypes, drug resistance, and response.
- 104 driver mutations from 25 key solid tumor genes
- Only 5 ng DNA input requirement from FFPE, fresh/frozen, and cells
- Sensitivity and Specificity above 95% on solid tumor samples with >5% allele frequency*
- Concordance with gold standard mutational analysis techniques
- Simultaneous multi-analyte profiling with Vantage 3D RNA and Protein Assays
*Validated on internal reference materials. Data may vary with the various quality of FFPE samples.
Curated Content
| Feature | Specifications |
| Solid Tumor Coverage Examples | Examples such as lung adenocarcinoma, thyroid carcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and melanoma |
| Recommended amount of starting material | 5 ng total genomic DNA |
| Sample types supported | Human genomic DNA from FFPE samples, fresh or frozen tissue, or cell lines |
| Sensitivity and Specificity | > 95%* |
| Number of SNVs detected | 104 driver mutations + 20 controls |
| Time to Results | < 24 hours |
| nCounter® Digital Analyzer throughput | 12 samples/2.7 hours |
| Data Analysis | nSolver™ Analysis 4.0 (Research use only) |
*Might vary by FFPE quality
- nCounter® Vantage 3D™ DNA SNV Solid Tumor Panel Product Bulletin
- Gene list: nCounter® Vantage 3D™ SNV Solid Tumor
104 mutations and 20 controls for use as a stand-alone protein assay or for use with Vantage 3D RNA and Fusions - Presented Posters
Assay Overview MAN-10037
- Sample Prep (FFPE) MAN-10050
- Sample Prep (Fresh/Frozen) MAN-10051
- Pre-amplification MAN-10052
- Hybridization MAN-10055
nCounter® Vantage 3D™ DNA SNV Qualification Kit MAN-10039
All About SNV Analysis in nSolver & Advanced Analysis MAN-10075
| Product | Description | Catalog Number | Unit Size |
| nCounter® Vantage 3D DNA SNV Solid Tumor Panel (CSO) | Contains code set for 104 solid tumor actionable mutation over 25 genes. Includes Pre-Amplification Reagents. To be used as a stand-alone DNA assay or with nCounter Vantage 3D Protein and RNA. No Master Kit | VDXC-HST-12 | 12 Reactions |
| nCounter® Vantage 3D SNV Qualification Kit (CSO) | Contains synthetic oligos to qualify nCounter instruments before testing SNV Panel. To be used only one time for first time SNV users. No Master Kit. | VDXC-QualK-12 | 12 Reactions |
For Research Use Only. Not for use in diagnostic procedures.