Quantitative Protein Profiling in FFPE to Characterize Toxicities Associated with Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (including anti-CTLA-4 and anti-PD-1) have shown substantial clinical success in many cancers but have been linked to rare immune-related adverse events (irSAE). The molecular underpinnings of irSAE have not been extensively explored. Therefore, NanoString Technologies has sought to characterize the immune composition of tissue affected by immune checkpoint inhibitor-mediated inflammation with a focus on colitis and neurologic toxicity.
Jun 20, 2017 9:00am
Best Practices for Analytically Validating Gene Expression Signatures for Oncology-based Applications
Feb 28, 2017 6:00am