Accelerating Immuno-Oncology Research with the PanCancer IO 360™ Gene Expression Panel, Advanced Data Analysis Service, and Signature Development
|SPEAKER:||Sarah Warren, Ph.D. and Patrick Danaher, Ph.D.|
Dec 07, 2017 - Dec 07, 2017
Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechanisms, enables potential development of novel therapeutics, and allows for possible identification of responder/non-responder populations in immunotherapy research. The NanoString PanCancer IO 360™ Panel is a 770 target, multiplexed gene expression panel developed for characterization of expression patterns from the tumor, immune system, and stroma. It contains the Tumor Inflammation Signature, which includes 18 functional genes known to be associated with response to PD-1/PD-L1 inhibitors pathway blockade. The IO 360 panel also contains gene content to profile other mechanisms of immune evasion as well as biology relevant to tumor growth and persistence. Furthermore, NanoString has developed additional signatures that describe particular aspects of biology relevant to tumor-immune evasion, including signatures to detect 14 different immune cell populations and 15 additional biological activities such as antigen presentation, mismatch repair deficiency, cytotoxicity, interferon activity, angiogenesis, and stromal abundance. Capturing biological activity with gene signatures can reduce complexity of data analysis and lead to improved sensitivity to detect differences between samples. The signatures being offered with the IO 360 panel are part of a new data analysis service to facilitate research and enable greater characterization of mechanisms of immune evasion.