Genetics of Osteoarthritis: From Man to Fish to Mouse
Mar 4, 11 AM GMT, 2 PM SGT, 10 AM PST
Dr. Jurynec’s group works to discover and understand the functions of genes underlying the onset and progression of osteoarthritis and other bone and joint diseases. They use a combination of approaches including human genetics, bioinformatics, and model organisms (zebrafish and mouse) to elucidate the molecular and biological mechanisms that lead to changes in the synovial joint and contribute to the disease phenotype.
In this webinar, Dr. Jurynec will talk about his lab’s approach to the discovery of osteoarthritis (OA) susceptibility genes using genetics and gene expression analysis, from using both zebrafish and mouse models to test the functional impact of candidate variants to using a mouse model to understand the impact of human variants on the onset and progression of OA. Dr. Jurynec will discuss the discovery of the OA-associated RIPK2 allele and how this variant allele causes hyperactive inflammatory signaling and, when introduced into mice, results in increased susceptibility to OA.