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COVID-19 Respiratory Disease Syndrome: Dissecting the root cause of its severity

Masthead
  • 10:00 am - 11:00 am
Speakers: Alain Borczuk, MD & Robert Schwartz, MD, PhD - Weill Cornell Medicine

Missed AMP 2020? Join us for this webinar broadcast from the NanoString AMP corporate workshop and catch up on what you missed. Hear from Alain Borczuk, MD, and Rob Schwartz, MD, PhD, both from Weill Cornell Medical College to learn about how the nCounter® Analysis System and GeoMx® Digital Spatial Profiler (DSP) were used to profile differential gene expression in lung tissue infected with SARS-CoV-2 compared to lung tissue from influenza related acute respiratory distress syndrome (ARDS), non-viral ARDS, and normal samples. They found a consistent induction of HLA and IFN associated genes in COVID-19 samples compared to normal controls, with severe COVID-19 samples exhibiting a classic IFN-gamma response. Non-viral ARDS samples behaved similarly to samples with low amounts of COVID-19 damage but gave an alternate IFN signature. Overall the COVID-19 and ARDS samples were rather heterogenous in their expression response, while the normal samples and those with influenza infections exhibited a more homogeneous response.

For Research Use Only.  Not for Use in Diagnostic Procedures.