WELCOME This newsletter includes recent news and information from NanoString Technologies and our community. William D. Young Joins NanoString Technologies as Executive Chairman of the Board Mr. Young has a long record of leadership in the life sciences industry. He joins NanoString after serving as Chairman and Chief Executive Officer of Monogram Biosciences, Inc., a pioneer in the field of personalized medicine. Prior to Monogram, he was Chief Operating Officer of Genentech. Before Genentech, he served in positions of increasing responsibility at Eli Lilly. Mr. Young currently serves as the Chairman of the Board of Biogen Idec, Inc., is a Director and Chairman Emeritus for BayBio, and is a Director at Theravance, Inc. Read More  NanoString Scopes Out Diagnostic Future, Considers Bay Area Expansion Xconomy's National Biotechnology Editor Luke Timmerman recently visited NanoString's Seattle offices to talk to Executive Chairman, Bill Young, about the future of the company. Read More  NanoString Chairman Sees Dx Opportunity for 'Elegantly Simple' Technology Bill Young recently spoke to GenomeWeb Editor Bernadette Toner about the vision for NanoString's technology in the diagnostics market. Read More  Coming Soon: Human miRNA Transcriptome CodeSet! Micro RNAs (miRNAs) are small, single-stranded, non-coding RNA molecules that have generated intense interest in the scientific community for their roles in tumor formation and other biological processes. NanoString is developing a unique new product for miRNA analysis: a single-tube, multiplexed assay for profiling the human miRNA transcriptome and related viral miRNAs using the nCounter Analysis System. The nCounter miRNA CodeSet contains more than 700 miRNAs from the latest version of miRBase and is easily amenable to the addition of new miRNAs as they are added to the database. With only 100ng of total RNA, the nCounter CodeSet for miRNA analysis provides a sensitive, accurate and cost-effective digital profiling solution capable of discriminating between miRNAs at single-base resolution. Stay tuned for more details. New nCounter Virtual Gene Sets nCounter Virtual Gene Sets accelerate research by offering CodeSets with pre-selected genes and pre-designed probes. Virtual Gene Sets are made-to-order and since probes are in inventory, CodeSets can be rapidly assembled and delivered. For a complete list of available Virtual Panels Read More  Now Available nCounter Virtual Jak-Stat Pathway Gene Set  Gene List | Product Data Sheet nCounter Virtual p53 Pathway Gene Set  Gene List | Product Data Sheet nCounter Virtual Wnt Pathway Gene Set  Gene List | Product Data Sheet nCounter Virtual Mouse Cancer Gene Set  Gene List | Product Data Sheet nCounter Virtual Mouse Inflammation Gene Set  Gene List | Product Data Sheet nCounter Virtual Mouse Stem Cell Gene Set  Gene List | Product Data Sheet nCounter Analysis System Quick Tour Learn how the nCounter Analysis System can put thousands of data points per day at your fingertips. The nCounter Quick Tour video will demonstrate how with less than 15 minutes of hands-on time you can hybridize, purify, and count millions of individual molecules, delivering high-quality data with incredible ease of use. Watch Now  Functional Cis-regulatory Genomics for Systems Biology Proc Natl Acad Sci U S A, February 2010 Researchers at the California Institute of Technology used the nCounter Analysis System to study the functional linkages of gene regulatory networks using the sea urchin as a model organism. They present a high-throughput approach to both discovery and quantitative characterization of cis-regulatory modules that increased the rate of cis-regulatory analysis by >100-fold compared with conventional one-by-one reporter assays. The authors write that this approach will qualitatively alter the practice of gene regulatory network construction as well as validation, and will impact many additional areas of regulatory system biology. Read More  Nuclear Entry of Activated MAPK Is Restricted in Primary Ovarian and Mammary Epithelial Cells PloS One, February 2010 Researchers from the University of Miami and Fox Chase Cancer Center used the nCounter Analysis System in combination with other methods to find that in primary cultures of breast and ovarian epithelial cells, phosphorylation and activation of ERK1/2 are disassociated from nuclear translocalization and transcription of downstream targets, such as c-Fos, suggesting that nuclear translocation is limited in primary cells. Read More			nCounter Analysis System Quick Tour. Watch Now  SCIENCE nCOUNTER In this edition of our newsletter we are profiling scientists from two core labs, both who have served as early access customers for the nCounter Analysis System. Toumy Guettouche, Ph.D Sylvester Comprehensive Cancer Center, University of Miami School of Medicine Dr. Guettoche is working on the development of a test for Human Papillomavirus Virus (HPV) that can detect more strains using the nCounter Analysis System. Read More  Patrick Descombes, Ph.D. National Centre of Competence in Research Frontiers in Genetics, University of Geneva A busy core lab housed at the University of Geneva Medical School and Hospital is offering services across Switzerland and Europe, and is hoping to expand its offering to customers outside of Europe as well. Read More  Have you recently published or presented interesting work using the nCounter Analysis System? Are you planning to? Please let us know and we may feature your work on our website and/or in an upcoming newsletter! UPCOMING EVENTS CHI microRNA Conference Cambridge, MA March 22-24, 2010 Join us for a seminar: Wednesday, March 24th 11:50 AM-12:20 PM Location: Grand Ballroom A Visit us at Booth 8. View Details  ACMG Albuquerque, NM March 23-28, 2010 Join us for a seminar: Friday, March 26th 12:00 PM-12:30 PM Location: Exhibit Theater 1 Poster Number 409 will be presented on Friday, March 26th, 10:30-11:30 AM. Visit us at Booth 431. View Details  AACR Washington, DC April 17-21, 2010 Visit us at Booth 1439. View Details  Join the nCounter Community now to get a free NanoString T-shirt and be entered to win a $3000 travel grant. Learn More
				www.NanoString.com
		© 2010 NanoString Technologies, Inc. All rights reserved. NanoString Technologies, NanoString nCounter, and Molecules That Count are trademarks of NanoString Technologies, Inc., in the United States and/or other countries. All other trademarks and/or service marks not owned by NanoString that appear in this document are the property of their respective owners.