NanoString Technologies

Featured Publications:

Turn discoveries into practical tools for routine analysis.

• Bock, C., et al.  “Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines.”  Cell 144, 439-452 (2011)

Access your FFPE archives with confidence - nCounter provides superior performance to PCR.

• Reis PP, et al. “mRNA transcript quantification in archival samples using multiplexed, color-coded probes.” BMC Biotechnol. 2011 May 9;11(1):46.

Digital sequencing + digital validation = data you can publish.

• Sun Z., et al. “Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing”  PloS ONE Vol 6-2, e17490 (2011).

Complete List of Publications:

• Ram O., et al. “Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells” Cell 2011 December 23.
• Ziller M J., et al. “Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation Across Human Cell Types” PLoS Genetics 2011 December 8.
• Gupta R K., et al. “Identifying Novel Transcriptional Components Controlling Energy Metabolism” Cell 2011 Dec 7.
• Janus J R., et al. “Linking Expression of FOXM1, CEP55 and HELLS to Tumorigenesis in Oropharyngeal Squamous Cell Carcinoma” The Laryngoscope 2011 Dec.
• Khan M., et al. “Regulation of the Probability of Mouse Odorant Receptor Gene Choice” Cell 2011 November 11.
• Northcott P.A., et al. “Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples” Acta Neuropathologica 2011 November 6.
• Ioffe YJ, et al. “Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?” Gynecol Oncol. 2011 Oct 14.
• Fresneau B., et al. “Vinblastine in the treatment of children and adolescents with refractory immune thrombocytopenia.” Am J Hematol. 2011 Sep;86(9):785-7.
• Guttman M., et al. “lincRNAs act in the circuitry controlling pluripotency and differentiation” Nature. 2011 Aug 28.
• Zhang W, et al. "Type-A response regulators are required for proper root apical meristem function through post-transcriptional regulation of PIN auxin efflux carriers" The Plant Journal. 2011 Jun 6
• Novikov, Aleksey, et al. "Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1b Production in Human Macrophages". J Immunol.  (2011)
• Finlay W. McNab et al. “Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active Tuberculosis” Eur. J. Immunol. 2011. 41: 1941–1947.
• Haynes K and Silver P. “Synthetic Reversal Of Epigenetic Silencing” J. Biol. Chem. 2011  jbc.C111.229567.
• Orlovsky K, et al. “Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.” PNAS May 10, 2011 vol. 108 no. 19 7956-7961.
• Reis PP, et al. “mRNA transcript quantification in archival samples using multiplexed, color-coded probes.” BMC Biotechnol. 2011 May 9;11(1):46.
• Gamer LW, et al. “BMPR-II is dispensable for formation of the limb skeleton” Genesis. 2011 May 2.
• Rabini M, et al. “Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells” Nature Biotechnology (2011).
• Cools T, et al. “The Arabidopsis thaliana Checkpoint Kinase WEE1 Protects against Premature Vascular Differentiation during Replication Stress.” Plant Cell. 2011 Apr 15.
• Kulkarni MM.  “Digital Multiplexed Gene Expression Analysis Using the NanoString nCounter System” Current Protocols in Molecular Biology, April 2011. 
• Beaume M, et al. “Orientation and expression of methicillin-resistant Staphylococcus aureus small RNAs by direct multiplexed measurements using the nCounter of NanoString technology.” J Microbiol Methods; 2011 Feb; 84(2):327-34
• Baugh LR, et al. “Sensitive and Precise Quantification of Insulin-Like mRNA Expression in Caenorhabditis elegans.” PLoS ONE (2011) 6(3).
• Yun L, et al. “Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid–immunoglobulin complexes in humans” J Clin Invest doi:10.1172/JCI44581.
• Chaussabel S, et al. “Blood Transcriptional Fingerprints to Assess the Immune Status of Human Subjects" Immunologic Signatures of Rejection (2011), Part 3, 105-125.
• Wurbel MA, et al. “CCL25/CCR9 Interactions Regulate Large Intestinal Inflammation in a Murine Model of Acute Colitis” PLoS One. 2011 Jan 25;6(1):e16442.
• Andersen JB, et al. “An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer”.  Sci. Transl. Med. 2, 54ra77 (2010).
• Kim C, et al. “Gene-expression-based prognostic assays for breast cancer” Nature Reviews Clinical Oncology 7, 340-347 (June 2010).
• Guiducci C., et al. “TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus” Nature.  465, 937–941 (17 June 2010).
• Sun Z, et al. “Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing”  PloS ONE Vol 6-2, e17490 (2011).
• Bock C, et al. “Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines”.  Cell. 44, 439–452, (2011).
• Peter IS,  et al. “The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage” Developmental Biology, Special Section: Gene Regulatory Networks for Development (340)(2), 188-199., 15 April 2010.
• Anakk S, et al. “Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis”. The Journal of Clinical Investigation. 10.1172 (2010).
• Kabacik S, et al. “Gene expression following ionising radiation: Identification of biomarkers for dose estimation and prediction of individual response”. Int. J. Radiat. Biol., Vol. 87; 1-15 (2010).
• Strobl-Mazzulla HP, et al.  “Histone Demethylase JmjD2A Regulates Neural Crest Specification”. Developmental Cell. Volume 19, Issue 3, 14 September 2010, Pages 460-468.
• Yassour M, et al. “Strand-specific RNA Sequencing Reveals Extensive Regulated Long Antisense Transcripts that are Conserved Across Yeast Species”.  Genome Biology, August 26, 2010; 11:R87.
• Garay J, et al. “Crosstalk Between PKA and Epac Regulates the Phenotypic Maturation and Function of Human Dendritic Cells”.  The Journal of Immunology 2010; 185:3227-3238.
• D’Angelo JA, et al. “The Cystine/Glutamate Antiporter Regulates Dendritic Cell Differentiation and Antigen Presentation”. The Journal of Immunology 2010; 185:3217-3226.
• Materna SC, et al. “High accuracy, high-resolution prevalence measurement for the majority of locally expressed regulatory genes in early sea urchin development”.  Gene Expression Patterns doi:10.1016/j.gep.2010.04.002 (2010).
• Dixit E, et al.  “Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity”.  Cell (2010 May) Vol. 141, Issue 4, 668-681.
• Nam J, et al. “Functional cis-regulatory genomics for systems biology”.  Proc Natl Acad Sci USA 2010 Feb 23;107(8):3930-5.
• Smith ER, et al. “Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells”.  PLoS One 2010 Feb 18;5(2):e9295.
• Ouellet M, et al.  “A rapid and inexpensive labeling method for microarray gene expression analysis”.  BMC Biotechnology 2009 Nov 25;9(1):97.
• Amit I, et al.  “Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses”.  Science 2009 Oct 9; Vol. 326. no. 5950, 257-263.
• Palamanda JR, et al. “Evaluation of CYP1A1 and CYP2B1/2 m-RNA Induction in Rat Liver Slices Using the NanoString Technology: A Novel Tool for Drug Discovery Lead Optimization”.  Drug Metabolism Letters 2009 Aug 3;(3):171-5.
• Payton JE, et al.  “High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples”.  The Journal of Clinical Investigation 119(6): 1714-1726 (2009).
• Vladislav MA, et al.  “Multiplexed measurements of gene signatures in different analytes using the NanoString nCounter Assay System”.  BMC Research Notes 2: 80 (2009).
• Yi-Hsien S, et al.  “A Perturbation Model of the Gene Regulatory Network for Oral and Aboral Ectoderm Specification in the Sea Urchin Embryo”.  Developmental Biology 329: 410-421 (2009).
• Birtwell S, et al.  Baugh LR, et al. “Sensitive and Precise Quantification of Insulin-Like mRNA Expression in Caenorhabditis elegans.” PLoS ONE (2011) 6(3).
• Geiss GK, et al.  “Direct multiplexed measurement of gene expression with color-coded probe pairs”.  Nature Biotechnology 26: 317-25 (2008).